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Ac-YVAD-CMK

Name: Ac-YVAD-CMK
Brand: TargetMol
SKU: T36347
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T36347Cas No. 178603-78-6

Alias Caspase-1 Inhibitor II, Ac-Tyr-Val-Ala-Asp-CMK, Ac-Tyr-Val-Ala-Asp-chloromethylketone

Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.

Ac-YVAD-CMK

🥰Excellent

Purity: 99.909%

Catalog No. T36347Alias Caspase-1 Inhibitor II, Ac-Tyr-Val-Ala-Asp-CMK, Ac-Tyr-Val-Ala-Asp-chloromethylketoneCas No. 178603-78-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
5 mg	$228	In Stock	In Stock
10 mg	$372	In Stock	In Stock
25 mg	$613	-	In Stock
50 mg	$869	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.909%

Resource Download

COA HPLC MS

Product Introduction

Bioactivity

Description	Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.
In vitro	Ac-YVAD-cmk (40 and 80 μM) reduces the expression of IL-1β and IL-18 in activated microglia[3].
In vivo	In SD rats, Ac-YVAD-cmk treatment (1 μg; injection into the left lateral ventricle) significantly decreases the protein levels of caspase-1 and mature IL-1β/IL-18 compared with the ICH group[3]. Ac-YVAD-cmk (12.5 μmol/kg) significantly reduces mortality from 83 to 33% in rats[4].
Synonyms	Caspase-1 Inhibitor II, Ac-Tyr-Val-Ala-Asp-CMK, Ac-Tyr-Val-Ala-Asp-chloromethylketone

Chemical Properties

Molecular Weight	540.99
Formula	C₂₄H₃₃ClN₄O₈
Cas No.	178603-78-6
Smiles	CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)CCl
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (166.4 mM), Sonication is recommended.

DMF: 10 mg/mL (18.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8485 mL	9.2423 mL	18.4846 mL	92.4232 mL
5 mM	0.3697 mL	1.8485 mL	3.6969 mL	18.4846 mL
10 mM	0.1848 mL	0.9242 mL	1.8485 mL	9.2423 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0924 mL	0.4621 mL	0.9242 mL	4.6212 mL
50 mM	0.0370 mL	0.1848 mL	0.3697 mL	1.8485 mL
100 mM	0.0185 mL	0.0924 mL	0.1848 mL	0.9242 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc