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Anti-Phospho-Rb2 p130 (Thr986) Antibody (8C579)
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Catalog No. TMAB-11233
Anti-Phospho-Rb2 p130 (Thr986) Antibody (8C579) is a Rabbit antibody targeting Phospho-Rb2 p130 (Thr986). Anti-Phospho-Rb2 p130 (Thr986) Antibody (8C579) can be used in WB,IP.
Anti-Phospho-Rb2 p130 (Thr986) Antibody (8C579)
Anti-Phospho-Rb2 p130 (Thr986) Antibody (8C579)
😃Good
Catalog No. TMAB-11233
Anti-Phospho-Rb2 p130 (Thr986) Antibody (8C579) is a Rabbit antibody targeting Phospho-Rb2 p130 (Thr986). Anti-Phospho-Rb2 p130 (Thr986) Antibody (8C579) can be used in WB,IP.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $470 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-Rb2 p130 (Thr986) Antibody (8C579) is a Rabbit antibody targeting Phospho-Rb2 p130 (Thr986). Anti-Phospho-Rb2 p130 (Thr986) Antibody (8C579) can be used in WB,IP. |
| Ig Type | IgG |
| Clone | 8C579 |
| Reactivity | Human,Mouse |
| Application | |
| Recommended Dose | WB: 1:1000-2000; IP: 1:20-50 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. |
| Immunogen | A synthesized peptide: human RBL2 around the phosphorylation site of T986 |
| Antigen Species | Human |
| Gene Name | RBL2 |
| Gene ID | |
| Protein Name | Retinoblastoma-like protein 2 |
| Uniprot ID | |
| Function | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Molecular Weight | Theoretical: 128 kDa. Actual: 128 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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