ENSA Protein, Human, Recombinant (His)

Name: ENSA Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-03411
Rating: 4.5 (1 reviews)

(Synonyms: endosulfine α, endosulfine alpha, ARPP-19e) Copy Product Info

Synonyms: endosulfine α, endosulfine alpha, ARPP-19e

Catalog No. TMPY-03411 Copy Product Info

ENSA Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 15.2 kDa and the accession number is O43768-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$48	7-10 days	7-10 days
10 µg	$76	7-10 days	7-10 days
20 µg	$118	7-10 days	7-10 days
50 µg	$237	7-10 days	7-10 days
100 µg	$458	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	ENSA Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 15.2 kDa and the accession number is O43768-1.
Species	Human
Expression System	E. coli
Tag	N-His
Accession Number	O43768-1
Construction	A DNA sequence encoding the mature form of human ENSA (O43768-1) (Met1-Glu121) was expressed with a polyhistide tag at the N-terminus. Predicted N terminal: His
Protein Purity	> 90 % as determined by SDS-PAGE
Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	endosulfine α, endosulfine alpha, ARPP-19e
Research Background	Endosulfine alpha, also known as ENSA, belongs to the endosulfine family. It is a highly conserved cAMP-regulated phosphoprotein (ARPP) family. Endosulfine alpha is widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. As a protein phosphatase inhibitor, ENSA specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase By similarity. Endosulfine alpha also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.

Chemical Properties

Molecular Weight

15.2 kDa (predicted); 18 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.