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AS 1892802

Catalog No. T22037 CAS 928320-12-1

AS 1892802 is a potent and selective inhibitor of ROCK. AS 1892802 exibits IC50 values of 52nM, 57nM and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respectively. The onset of antinociceptive effect of AS 1892802 is as fast as those of Tramadol and Diclofenac.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

AS 1892802, CAS 928320-12-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 178.00
25 mg	In stock	$ 397.00
50 mg	In stock	$ 589.00
100 mg	In stock	$ 843.00
500 mg	In stock	$ 1,730.00
1 mL * 10 mM (in DMSO)	In stock	$ 167.00

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Purity: 98.9%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AS 1892802 is a potent and selective inhibitor of ROCK. AS 1892802 exibits IC50 values of 52nM, 57nM and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respectively. The onset of antinociceptive effect of AS 1892802 is as fast as those of Tramadol and Diclofenac.
Targets&IC50	ROCK2 (rat):52nM, ROCK2 (huamn):52 nM

Molecular Weight	333.38
Formula	C20H19N3O2
CAS No.	928320-12-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 7.5 mg/mL (22.5 mM)

DMSO: 30.0 mg/mL (90.0 mM)

References and Literature

1. Yoshimi E, et al. Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis. J Pharmacol Exp Ther. 2010;334(3):955-963.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library TGF-beta/Smad Compound Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Bioactive Compound Library Kinase Inhibitor Library

Related Products

Related compounds with same targets

RKI1313 ROCK-IN-5 GSK180736A ROCK-IN-7 SAR407899 hydrochloride Afuresertib ROCK2-IN-7 ROCK2-IN-6

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AS 1892802 928320-12-1 Cell Cycle/Checkpoint Cytoskeletal Signaling Stem Cells ROCK AS1892802 AS-1892802 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.