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BT18

🥰Excellent
Catalog No. T13587Cas No. 924811-53-0

BT18 is a mimic with function similar to glial cell line-derived neurotrophic factor (GDNF). BT18 has an effect on RET receptor tyrosine kinase RetA and GDNF family receptor GFRα1 function.

BT18

BT18

🥰Excellent
Purity: 99.32%
Catalog No. T13587Cas No. 924811-53-0
BT18 is a mimic with function similar to glial cell line-derived neurotrophic factor (GDNF). BT18 has an effect on RET receptor tyrosine kinase RetA and GDNF family receptor GFRα1 function.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$34In StockIn Stock
5 mg$80In StockIn Stock
10 mg$147In StockIn Stock
25 mg$263In StockIn Stock
50 mg$398In StockIn Stock
100 mg$588In StockIn Stock
200 mg$852-In Stock
1 mL x 10 mM (in DMSO)$113In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.32%
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Product Introduction

Bioactivity
Description
BT18 is a mimic with function similar to glial cell line-derived neurotrophic factor (GDNF). BT18 has an effect on RET receptor tyrosine kinase RetA and GDNF family receptor GFRα1 function.
In vitro
BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines. BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines. BT18 (5-50 μM; 15 minutes) appears to phosphorylate RET in the concentration of 50 μM both in GFP-transfected and in GFRD1-transfected cells [1].
Chemical Properties
Molecular Weight637.64
FormulaC30H31F4N3O6S
Cas No.924811-53-0
SmilesCOc1ccc(cc1N1CCN(CC1)C(=O)c1ccc(F)cc1C(F)(F)F)S(=O)(=O)N1CCc2cc(OC)c(OC)cc2C1
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 98 mg/mL (153.69 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.18 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5683 mL7.8414 mL15.6828 mL78.4142 mL
5 mM0.3137 mL1.5683 mL3.1366 mL15.6828 mL
10 mM0.1568 mL0.7841 mL1.5683 mL7.8414 mL
20 mM0.0784 mL0.3921 mL0.7841 mL3.9207 mL
50 mM0.0314 mL0.1568 mL0.3137 mL1.5683 mL
100 mM0.0157 mL0.0784 mL0.1568 mL0.7841 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitBT-18BT18BT 18
Related Tags: buy BT18 | purchase BT18 | BT18 cost | order BT18 | BT18 chemical structure | BT18 in vitro | BT18 formula | BT18 molecular weight
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