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Chlorambucil

🥰Excellent
Catalog No. T0975Cas No. 305-03-3
Alias WR-139013, Chloroambucil, CB-1348

Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.

Chlorambucil

Chlorambucil

🥰Excellent
Purity: 98.45%
Catalog No. T0975Alias WR-139013, Chloroambucil, CB-1348Cas No. 305-03-3
Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.
Pack SizePriceAvailabilityQuantity
10 mg$33In Stock
25 mg$50In Stock
50 mg$63In Stock
100 mg$101In Stock
500 mg$239In Stock
1 mL x 10 mM (in DMSO)$54In Stock
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Purity:98.45%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.
SynonymsWR-139013, Chloroambucil, CB-1348
Chemical Properties
Molecular Weight304.21
FormulaC14H19Cl2NO2
Cas No.305-03-3
SmilesN(CCCl)(CCCl)C1=CC=C(CCCC(O)=O)C=C1
Relative Density.1.248 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 56 mg/mL (184.08 mM), Sonication is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 85 mg/mL (279.41 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.85 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.2872 mL16.4360 mL32.8720 mL164.3601 mL
5 mM0.6574 mL3.2872 mL6.5744 mL32.8720 mL
10 mM0.3287 mL1.6436 mL3.2872 mL16.4360 mL
20 mM0.1644 mL0.8218 mL1.6436 mL8.2180 mL
50 mM0.0657 mL0.3287 mL0.6574 mL3.2872 mL
100 mM0.0329 mL0.1644 mL0.3287 mL1.6436 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

WR139013WR 139013proteinsp53nuclearmutationsmalignanciesInhibitorinhibithistonesDNAAlkylatorDNAAlkylationDNA Alkylator/CrosslinkerDNA AlkylatorDNA AlkylationDNACrosslinkerChlorambucilCB1348CB 1348alkylator
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