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Chlorambucil
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Catalog No. T0975Cas No. 305-03-3
Alias WR-139013, Chloroambucil, CB-1348
Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.
Chlorambucil
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Purity: 98.45%
Catalog No. T0975Alias WR-139013, Chloroambucil, CB-1348Cas No. 305-03-3
Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $40 | In Stock | In Stock | |
| 50 mg | $56 | In Stock | In Stock | |
| 100 mg | $81 | In Stock | In Stock | |
| 500 mg | $163 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $54 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.45%
Appearance:Solid
Color:White
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Product Introduction
Chlorambucil AI Summary
Chlorambucil demonstrates a wide array of bioactivities, ranging from cytotoxic effects on various cancer cell lines to enzyme inhibition and potential use as an anticancer agent. In vitro, it exhibits beta-blocking activity with a significant score of 0.64 and cytotoxicity against multiple cell lines like murine leukemia P388, Chinese hamster ovary AA8, and K562 cells, with IC50 values ranging from 6800.0 nM to 298000.0 nM. Additionally, Chlorambucil has shown inhibition against various enzymes including beta-lactamase and chymotrypsin, and significant transporter and enzyme inhibition, such as aldose reductase and cytochrome P450 2D6.
The compound also exhibits alkylating activity, a partition coefficient (logD) of 0.75, and varied cellular uptake. Its antitumor properties extend to different tumor models in animals, enhancing lifespan and showing dose-dependent cytotoxicity. Furthermore, it has shown growth inhibition activity in different cancer cell lines, indicating a potential for anticancer development.
In terms of pharmacokinetics, Chlorambucil presents moderate lipophilicity, high oral bioavailability, and a half-life of approximately 7.75 hours in bioactivity related to NBP alkylation. It also demonstrates a calculated logD7.4 of 1.47, indicating moderate membrane permeability.
Overall, Chlorambucil’s multifaceted biological activities, including significant cytotoxic, enzyme inhibitory, and antitumor effects, alongside favorable pharmacokinetic properties, highlight its potential as a versatile therapeutic agent in cancer treatment and other bioactive applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. |
| Synonyms | WR-139013, Chloroambucil, CB-1348 |
| Molecular Weight | 304.21 |
| Formula | C14H19Cl2NO2 |
| Cas No. | 305-03-3 |
| Smiles | N(CCCl)(CCCl)C1=CC=C(CCCC(O)=O)C=C1 |
| Relative Density. | 1.248 g/cm3 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 56 mg/mL (184.08 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 85 mg/mL (279.41 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.85 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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