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Sinefungin

Name: Sinefungin
Brand: TargetMol
SKU: T16886
Price: 222 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16886Cas No. 58944-73-3

Alias Antibiotic 32232RP, Adenosyl-Ornithine, A-9145

Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates renal fibrosis by inhibiting H3K4 methylation.

Sinefungin

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Purity: 98.12%

Catalog No. T16886Alias Antibiotic 32232RP, Adenosyl-Ornithine, A-9145Cas No. 58944-73-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$222	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.12%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates renal fibrosis by inhibiting H3K4 methylation.
Targets&IC50	A549 cells:72.93 μM (CC50), HepG2 cells:> 100 μM (CC50), HEK293 cells:> 500 μM (CC50), Sf9 cells:8.6 μM
In vitro	Sinefungin (0.5 or 1.0 μg/mL, 60 minutes) mitigates TGF-β1-induced α-SMA increase and inhibits histone H3K4 monomethylation upregulation in renal epithelial and fibroblast cells [2].
In vivo	In obstructive nephropathy, Sinefungin (10 mg/kg, per day immediately after UUO) improves renal fibrosis [2].
Synonyms	Antibiotic 32232RP, Adenosyl-Ornithine, A-9145

Chemical Properties

Molecular Weight	381.39
Formula	C₁₅H₂₃N₇O₅
Cas No.	58944-73-3
Smiles	N[C@@H](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Relative Density.	1.91 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 95 mg/mL (249.09 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.6220 mL	13.1099 mL	26.2199 mL	131.0994 mL
5 mM	0.5244 mL	2.6220 mL	5.2440 mL	26.2199 mL
10 mM	0.2622 mL	1.3110 mL	2.6220 mL	13.1099 mL
20 mM	0.1311 mL	0.6555 mL	1.3110 mL	6.5550 mL
50 mM	0.0524 mL	0.2622 mL	0.5244 mL	2.6220 mL
100 mM	0.0262 mL	0.1311 mL	0.2622 mL	1.3110 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc