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Sinefungin

Name: Sinefungin
Brand: TargetMol
SKU: T16886
Price: 222 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Antibiotic 32232RP, Adenosyl-Ornithine, A-9145) Copy Product Info

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Synonyms: Antibiotic 32232RP, Adenosyl-Ornithine, A-9145

Catalog No. T16886 Copy Product Info

Purity: 98.12%

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Sinefungin (Adenosyl-Ornithine) belongs to natural products and is an mRNA methyltransferase inhibitor with broad-spectrum antiviral activity. This compound possesses cell permeability and is commonly used in antiviral mechanism research and antiviral drug development.

Cas No. 58944-73-3

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$222	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.12%

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Sinefungin (Adenosyl-Ornithine) belongs to natural products and is an mRNA methyltransferase inhibitor with broad-spectrum antiviral activity. This compound possesses cell permeability and is commonly used in antiviral mechanism research and antiviral drug development.
Targets & IC50	A549 cells:72.93 μM (CC50), Sf9 cells:8.6 μM, HepG2 cells:> 100 μM (CC50), HEK293 cells:> 500 μM (CC50)
In vitro	Methods: The in vitro activity of Sinefungin was evaluated using a methyltransferase (MTase) inhibition assay, with RSV MTase-CTD protein and L-P complex as targets. Proteins were incubated with GpppG-RSV9 RNA in reaction buffer containing SAM and ³H-SAM at 30°C for 3 hours, and detected by filter binding assay. Results: Sinefungin inhibited MTase activity in a dose-dependent manner, with IC50 values of 6.4 μM and 9.8 μM, respectively. [1]
In vivo	Methods: The in vivo activity of Sinefungin was evaluated using NBSGW mouse models. MNX1-transduced FL-HSPC were pretreated with 5 μM Sinefungin and then transplanted into non-irradiated mice. Results: Mice in the Sinefungin-treated group did not develop leukemia and showed significantly prolonged survival, while all mice in the control group died, confirming that Sinefungin can block MNX1-induced AML development.[2]
Synonyms	Antibiotic 32232RP, Adenosyl-Ornithine, A-9145

Chemical Properties

Molecular Weight	381.39
Formula	C₁₅H₂₃N₇O₅
Cas No.	58944-73-3
Smiles	N[C@@H](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Relative Density.	1.91 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 95 mg/mL (249.09 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.6220 mL	13.1099 mL	26.2199 mL	131.0994 mL
5 mM	0.5244 mL	2.6220 mL	5.2440 mL	26.2199 mL
10 mM	0.2622 mL	1.3110 mL	2.6220 mL	13.1099 mL
20 mM	0.1311 mL	0.6555 mL	1.3110 mL	6.5550 mL
50 mM	0.0524 mL	0.2622 mL	0.5244 mL	2.6220 mL
100 mM	0.0262 mL	0.1311 mL	0.2622 mL	1.3110 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc