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NVS-PI3-4

Name: NVS-PI3-4
Brand: TargetMol
SKU: T36315
Rating: 4.5 (1 reviews)

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Catalog No. T36315Cas No. 941580-60-5

Alias NVS-PI3-4

NVS-PI3-4 is a highly selective inhibitor of the enzyme PI3Kγ. It is specifically designed for use in scientific investigations related to allergies, inflammatory conditions, and cancerous diseases[1][2].

NVS-PI3-4

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Catalog No. T36315Alias NVS-PI3-4Cas No. 941580-60-5

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$766	6-8 weeks	6-8 weeks
50 mg	$995	6-8 weeks	6-8 weeks
100 mg	$1,590	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	NVS-PI3-4 is a highly selective inhibitor of the enzyme PI3Kγ. It is specifically designed for use in scientific investigations related to allergies, inflammatory conditions, and cancerous diseases[1][2].
In vitro	NVS-PI3-4 demonstrates high cellular selectivity for PI3Kγ, reduces IgE/antigen-mediated phosphorylation of PKB/Akt in p110δDA, and does not specifically accumulate in mast cells (5 μM; 30 minutes; BMMCs)[2].
Synonyms	NVS-PI3-4

Chemical Properties

Molecular Weight	402.51
Formula	C₂₀H₂₆N₄O₃S
Cas No.	941580-60-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (621.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (8.2 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4844 mL	12.4221 mL	24.8441 mL	124.2205 mL
5 mM	0.4969 mL	2.4844 mL	4.9688 mL	24.8441 mL
10 mM	0.2484 mL	1.2422 mL	2.4844 mL	12.4221 mL
20 mM	0.1242 mL	0.6211 mL	1.2422 mL	6.2110 mL
50 mM	0.0497 mL	0.2484 mL	0.4969 mL	2.4844 mL
100 mM	0.0248 mL	0.1242 mL	0.2484 mL	1.2422 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc