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Sulfaquinoxaline

Name: Sulfaquinoxaline
Brand: TargetMol
SKU: T1177
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1177Cas No. 59-40-5

Alias Sulphaquinoxaline, Sulfabenzpyrazine, Avicocid

Sulfaquinoxaline (Sulfabenzpyrazine) is an antiprotozoal agent.

Sulfaquinoxaline

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Purity: 99.81%

Catalog No. T1177Alias Sulphaquinoxaline, Sulfabenzpyrazine, AvicocidCas No. 59-40-5

Sulfaquinoxaline (Sulfabenzpyrazine) is an antiprotozoal agent.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$34	In Stock	In Stock
500 mg	$48	In Stock	In Stock
1 g	$70	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:White to Yellow

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COA LCMS HNMR

Product Introduction

Sulfaquinoxaline AI Summary

Sulfaquinoxaline exhibits a diverse range of bioactivities across various assays. It demonstrates potent inhibition of Lamin A splicing with a potency of 56.2 nM and shows inhibitory effects on Cytochrome P450 2C9 with a potency of 3981.1 nM, confirmed by an AC50 value of 3981.07 nM in the Cytochrome panel assay. In NCI human tumor cell line growth inhibition assays, the compound's GI50 values vary significantly from 10.0 nM to 100,000.0 nM across different cell lines. Additionally, it shows activity in assays for the Agonist of gsp mutation, Integrin-Mediated Alleviation for Muscular Dystrophy, and PTHR Inhibitors. In antiviral screening, Sulfaquinoxaline blocks the entry of Ebola Virus across channels with AC50 values ranging from 1.778 µM to 35481.3 nM and shows activity against SARS-CoV-2, with an IC50 value greater than 20,000.0 nM in VERO-6 cells. However, it lacks significant antibacterial and antifungal activities, with MIC values exceeding 10,000.0 nM and does not exhibit cytotoxicity against HEK293 cells, having a CC50 value also above 10,000.0 nM. Additionally, it acts as an inhibitor in an HDAC6 enzymatic assay, showing -38.71% inhibition with a commercial peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Sulfaquinoxaline (Sulfabenzpyrazine) is an antiprotozoal agent.
Synonyms	Sulphaquinoxaline, Sulfabenzpyrazine, Avicocid

Chemical Properties

Molecular Weight	300.34
Formula	C₁₄H₁₂N₄O₂S
Cas No.	59-40-5
Smiles	NC1=CC=C(C=C1)S(=O)(=O)NC1=NC2=CC=CC=C2N=C1
Relative Density.	1.3196 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 7.5 mg/L, Sonication is recommended.

DMSO: 250 mg/mL (832.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (16.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3296 mL	16.6478 mL	33.2956 mL	166.4780 mL
5 mM	0.6659 mL	3.3296 mL	6.6591 mL	33.2956 mL
10 mM	0.3330 mL	1.6648 mL	3.3296 mL	16.6478 mL
20 mM	0.1665 mL	0.8324 mL	1.6648 mL	8.3239 mL
50 mM	0.0666 mL	0.3330 mL	0.6659 mL	3.3296 mL
100 mM	0.0333 mL	0.1665 mL	0.3330 mL	1.6648 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc