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RSH-7

Catalog No. T73549 CAS 2764609-97-2

RSH-7 is a potent dual inhibitor of BTK and FLT3, with IC50s of 47 and 12 nM, respectively.RSH-7 has antiproliferative and antitumor activities, inducing apoptosis and inhibiting BTK and FLT3 signaling.

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RSH-7, CAS 2764609-97-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
5 mg	In stock	$ 263.00
10 mg	In stock	$ 428.00
25 mg	In stock	$ 813.00
50 mg	In stock	$ 1,180.00
100 mg	In stock	$ 1,620.00
500 mg	In stock	$ 3,230.00

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Purity: 98.31%

Biological Description

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Description	RSH-7 is a potent dual inhibitor of BTK and FLT3, with IC50s of 47 and 12 nM, respectively.RSH-7 has antiproliferative and antitumor activities, inducing apoptosis and inhibiting BTK and FLT3 signaling.
Targets&IC50	BTK:47 nM, FLT3:12 nM
In vitro	RSH-7 (1-1000 nM; 72 h) exhibits antiproliferative activities for Jeko-1, MV-4-11, Molt4, and K562 cells with IC50 values of 17 nM, 3 nM, 11 nM, and 930 nM respectively.[1] RSH-7 (1-1000 nM; 72 h) dose-dependently reduces the expression of p-BTK (TYR223), p-PLCγ(Tyr1217), p-FLT3 (Tyr589), and p-STAT5 (TYR694).[1] RSH-7 (1-1000 nM; 72 h) dose-dependently triggers apoptosis and upregulates the expression of BAX, p53, and cleaved caspase 3 in Jeko-1 cells.[1]
In vivo	RSH-7 (25, 50 mg/kg; i.p.; daily for 16 days; Female NOD/SCID mice) suppressed tumor growth in a dose-dependent manner, with tumor growth inhibition (TGI) values of 66.95% and 79.78% at doses of 25 and 50 mg/kg.[1]

Molecular Weight	436.49
Formula	C22H25FN8O
CAS No.	2764609-97-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 75 mg/mL (171.83 mM), Sonication is recommended.

References and Literature

1. Ran F, et al. Development of novel hydrazidoarylaminopyrimidine-based BTK/FLT3 dual inhibitors with potent in vivo anti-hematological malignancies effects. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114913.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Kinase Inhibitor Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RSH-7 2764609-97-2 Angiogenesis Apoptosis Tyrosine Kinase/Adaptors BTK FLT inhibitor inhibit

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