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RSH-7

Name: RSH-7
Brand: TargetMol
SKU: T73549
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T73549Cas No. 2764609-97-2

RSH-7 is a potent dual inhibitor of BTK and FLT3, with IC50s of 47 and 12 nM, respectively.RSH-7 has antiproliferative and antitumor activities, inducing apoptosis and inhibiting BTK and FLT3 signaling.

RSH-7

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Purity: 98.31%

Catalog No. T73549Cas No. 2764609-97-2

Pack Size	Price	Availability
1 mg	$41	In Stock
5 mg	$111	In Stock
10 mg	$180	In Stock
25 mg	$342	In Stock
50 mg	$496	In Stock
100 mg	$680	In Stock
200 mg	$896	In Stock

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Batch Information

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Purity:98.31%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	RSH-7 is a potent dual inhibitor of BTK and FLT3, with IC50s of 47 and 12 nM, respectively.RSH-7 has antiproliferative and antitumor activities, inducing apoptosis and inhibiting BTK and FLT3 signaling.
Targets&IC50	BTK:47 nM, FLT3:12 nM
In vitro	RSH-7 (1-1000 nM; 72 h) demonstrates antiproliferative activities against Jeko-1, MV-4-11, Molt4, and K562 cells with IC50 values of 17 nM, 3 nM, 11 nM, and 930 nM, respectively.[1] It dose-dependently reduces the expression of p-BTK (TYR223), p-PLCγ(Tyr1217), p-FLT3 (Tyr589), and p-STAT5 (TYR694), and triggers apoptosis while upregulating BAX, p53, and cleaved caspase 3 in Jeko-1 cells.[1]
In vivo	RSH-7 (25, 50 mg/kg; i.p.; daily for 16 days; Female NOD/SCID mice) suppressed tumor growth in a dose-dependent manner, with TGI values of 66.95% and 79.78% at doses of 25 and 50 mg/kg, respectively.[1]

Chemical Properties

Molecular Weight	436.49
Formula	C₂₂H₂₅FN₈O
Cas No.	2764609-97-2
Smiles	N(C1=C(C(NN)=O)C=CC=C1)C2=NC(NC3=CC=C(C=C3)N4CCN(C)CC4)=NC=C2F

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 75 mg/mL (171.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2910 mL	11.4550 mL	22.9100 mL	114.5502 mL
5 mM	0.4582 mL	2.2910 mL	4.5820 mL	22.9100 mL
10 mM	0.2291 mL	1.1455 mL	2.2910 mL	11.4550 mL
20 mM	0.1146 mL	0.5728 mL	1.1455 mL	5.7275 mL
50 mM	0.0458 mL	0.2291 mL	0.4582 mL	2.2910 mL
100 mM	0.0229 mL	0.1146 mL	0.2291 mL	1.1455 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc