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Daphnoretin

Name: Daphnoretin
Brand: TargetMol
SKU: T4S1335
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4S1335Cas No. 2034-69-7

Alias Thymelol, Dephnoretin

1. Daphnoretin (Thymelol) has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through promoting apoptosis in a mitochondria-mediated way. 3. Daphnoretin causes death of HOS cells by blocking cells successively in G2/M phases and activating the caspase-3 pathway.

Daphnoretin

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Purity: 99.85%

Catalog No. T4S1335Alias Thymelol, DephnoretinCas No. 2034-69-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$50	In Stock	In Stock
10 mg	$70	In Stock	In Stock
25 mg	$113	In Stock	In Stock
50 mg	$163	In Stock	In Stock
100 mg	$239	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.85%

Color:White

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COA

Product Introduction

Daphnoretin AI Summary

Daphnoretin demonstrates significant bioactivity across various biological targets and assays. It inhibits the growth of mouse EAC cells xenografted in CF1 mice at a dose of 3 mg/kg/day intraperitoneally, achieving an impressive inhibition rate of 97.0%. The compound also shows cytotoxicity against mouse P388 cells with effective doses (ED50) of 2.2 µg/mL and 3.4 µg/mL. Additionally, it inhibits rat DNA polymerase beta lyase activity with an IC50 value of 122300 nM after 30 minutes. Daphnoretin targets multiple enzymes and proteins, including hydroxysteroid dehydrogenase 4 (HSD17B4) with a potency of 31622.8 nM, and human Jumonji Domain Containing 2E (JMJD2E) with potencies of 35481.3 nM and 25118.9 nM. It inhibits Tyrosyl-DNA Phosphodiesterase (TDP1) at 35481.3 nM, Aldehyde Dehydrogenase 1 (ALDH1A1) at 25118.9 nM and 17782.8 nM, and Tau fibril formation at 44668.4 nM. The compound also shows inhibitory activity against Anthrax Lethal Toxin Internalization (12589.3 nM), 15-Hydroxyprostaglandin Dehydrogenase (HPGD) at 35481.3 nM, and DNA Polymerase Beta at 44668.4 nM. Furthermore, Daphnoretin acts as an activator and substrate of Cytochrome P450 3A4 with a potency of 501.2 nM, and modulates lipid storage at 35481.3 nM. It inhibits the Rango-Importin beta complex (35481.3 nM), polymerases Iota (63095.7 nM) and Kappa (354.8 nM), and the malarial parasite plastid (9285.0 nM). It induces DNA re-replication in MCF 10a normal breast cells at 20596.2 nM and inhibits Pin1 (79432.8 nM). Additionally, it acts as an agonist (79432.8 nM) and antagonist (50118.7 nM) of EPAC1, inhibits MBNL1-poly(CUG) RNA binding (6309.6 nM), and Human Apurinic/apyrimidinic Endonuclease 1 (APE1) at 44668.4 nM. In cellular models, Daphnoretin inhibits human Dipeptidyl Peptidase-4 (DPP4) with an IC50 of 87100.0 nM and induces cell cycle arrest in human MCF7 and MDA-MB-231 cells, with IC50 values of 2000.0 nM and 1000.0 nM, respectively, leading to accumulation of cells in G0-G1, S, and G2/M phases. It also exhibits inhibitory activity against porcine pancreas alpha-amylase and Saccharomyces cerevisiae alpha-glucosidase with IC50 values of 90.0 µg/mL and 86.0 µg/mL, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Daphnoretin (Thymelol) has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through promoting apoptosis in a mitochondria-mediated way. 3. Daphnoretin causes death of HOS cells by blocking cells successively in G2/M phases and activating the caspase-3 pathway.
Synonyms	Thymelol, Dephnoretin

Chemical Properties

Molecular Weight	352.29
Formula	C₁₉H₁₂O₇
Cas No.	2034-69-7
Smiles	COc1cc2cc(Oc3ccc4ccc(=O)oc4c3)c(=O)oc2cc1O
Relative Density.	1.501g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (177.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8386 mL	14.1929 mL	28.3857 mL	141.9285 mL
5 mM	0.5677 mL	2.8386 mL	5.6771 mL	28.3857 mL
10 mM	0.2839 mL	1.4193 mL	2.8386 mL	14.1929 mL
20 mM	0.1419 mL	0.7096 mL	1.4193 mL	7.0964 mL
50 mM	0.0568 mL	0.2839 mL	0.5677 mL	2.8386 mL
100 mM	0.0284 mL	0.1419 mL	0.2839 mL	1.4193 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc