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Simotinib

Catalog No. T35916 CAS 944258-89-3

Synonyms: AL-6802, SIM-6802

Simotinib (AL-6802) is a selective and orally bioactive EGFR tyrosine kinase inhibitor (IC50: 19.9 nM) with anti-tumour activity for the study of non-small cell lung cancer.

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Simotinib, CAS 944258-89-3

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,080.00
50 mg	8-10 weeks	$ 1,410.00
100 mg	8-10 weeks	$ 1,990.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Purity: 99.7%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Simotinib (AL-6802) is a selective and orally bioactive EGFR tyrosine kinase inhibitor (IC50: 19.9 nM) with anti-tumour activity for the study of non-small cell lung cancer.
Targets&IC50	EGFR:19.9 nM
In vitro	In vitro studies have shown that sunitinib inhibits the growth of EGFR and EGFR-overexpressing human A431 tumor cells in a dose-dependent manner, with no significant activity against other kinases examined in the study[1].
In vivo	Multiple doses of sunitinib reduced rat body weight by decreasing food intake, similar to human patients, indicating adverse effects of sunitinib on the gastrointestinal tract[2].

Synonyms	AL-6802, SIM-6802
Molecular Weight	500.95
Formula	C25H26ClFN4O4
CAS No.	944258-89-3

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (199.60 mM), when pH is adjusted to 3 with HCl. Sonication is recommended.

References and Literature

1. Hu XS, et al. Safety, tolerability, and pharmacokinetics of simotinib, a novel specific EGFR tyrosine kinase inhibitor, in patients with advanced non-small cell lung cancer: results of a phase Ib trial. Cancer Manag Res. 2019;11:4449-4459. Published 2019. 2. Zhu Q,et al. Drug interaction studies reveal that simotinib upregulates intestinal absorption by increasing the paracellular permeability of intestinal epithelial cells. Drug Metab Pharmacokinet. 2014;29(4):317-24.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Simotinib 944258-89-3 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR AL-6802 SIM-6802 inhibitor inhibit

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