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Anti-Insulin Receptor Antibody (1Q226)

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Catalog No. TMAY-01627
Alias Insulin Receptor, HHF5, CD220

Anti-Insulin Receptor Antibody (1Q226) is a Mouse antibody targeting Insulin Receptor. Anti-Insulin Receptor Antibody (1Q226) can be used in IHC-P.

Anti-Insulin Receptor Antibody (1Q226)

Anti-Insulin Receptor Antibody (1Q226)

😃Good
Catalog No. TMAY-01627Alias Insulin Receptor, HHF5, CD220
Anti-Insulin Receptor Antibody (1Q226) is a Mouse antibody targeting Insulin Receptor. Anti-Insulin Receptor Antibody (1Q226) can be used in IHC-P.
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100 μL$199 7-10 days
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Product Introduction

Bioactivity
Description
Anti-Insulin Receptor Antibody (1Q226) is a Mouse antibody targeting Insulin Receptor. Anti-Insulin Receptor Antibody (1Q226) can be used in IHC-P.
AliasInsulin Receptor, HHF5, CD220
Ig Type
Monoclonal Mouse IgG1
Clone
1Q226
Reactivity
Human
Verified Activity
1. Immunochemical staining of human INSR in human placenta with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).

2. Immunochemical staining of human INSR in human kidney with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Application
IHC-P
Recommended Dose
IHC-P: 1:100-1:500
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Insulin Receptor/INSR/CD220 (rh Insulin Receptor/INSR/CD220; TMPY-01149; NP_001073285.1; Met1-Lys944). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundINSR (Insulin receptor), also known as CD220, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). IRS-1 binding and phosphorylation eventually lead to an increase in the high-affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues. INSR isoform long and isoform short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin, and is found as a hybrid receptor with IGF1R which also binds IGF1 in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen, and placenta. Defects in Insulin Receptor/INSR are the cause of Rabson-Mendenhall syndrome (Mendenhall syndrome), insulin resistance (Ins resistance), leprechaunism (Donohue syndrome), and familial hyperinsulinemic hypoglycemia 5 (HHF5). It may also be associated with noninsulin-dependent diabetes mellitus (NIDDM).
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human Insulin Receptor/INSR/CD220 Protein (TMPY-01149)
Antigen Species
Human
Biology Area
Receptor Tyrosine Kinases (RTKs)
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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