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Histamine

Name: Histamine
Brand: TargetMol
SKU: T0965
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0965Cas No. 51-45-6

Alias Ergamine

Histamine (Ergamine) is an amine derived by the enzymatic decarboxylation of histamine. Histamine is a potent stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a neurotransmitter of central action.

Histamine

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Purity: 99.87%

Catalog No. T0965Alias ErgamineCas No. 51-45-6

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$34	In Stock	In Stock
100 mg	$48	In Stock	In Stock
200 mg	$51	In Stock	In Stock
500 mg	$56	-	In Stock
1 g	$68	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.87%

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Histamine AI Summary

Histamine exhibits a range of bioactivities including both activation and inhibition of various enzymes and receptors. It shows in vitro activation of Human cloned isozyme carbonic anhydrase I (KA = 2.0 uM), carbonic anhydrase II (KA = 125.0 uM), and carbonic anhydrase IV from bovine lung microsomes (KA = 41.0 uM). Additionally, the compound activates multiple recombinant carbonic anhydrase isoforms, with varying affinities for CA1, CA2, CA4, CA13, and others, highlighting its potential as a modulator of carbonic anhydrase enzymatic activity. Histamine also demonstrates bioactivity toward histamine receptors. It functions as an agonist at the human histamine H1, H2, H3, and H4 receptors with varying potency (EC50 = 190.55 nM for H1, EC50 = 1202.26 nM for H2, EC50 = 25.12 nM for H3, EC50 = 11.02 nM for H4). The compound inhibits histamine binding to the H3 receptor (Ki = 12.59 nM for human H3) and the H4 receptor (Ki = 19.95 nM for human H4), indicating significant receptor affinity and potential regulatory effects on histamine-mediated pathways. In addition to these properties, Histamine exhibits cardiovascular effects, including decreases in systolic and diastolic blood pressure and heart rate in anesthetized rats, indicating potential hypotensive activity. Moreover, the compound shows diverse interactions with other biological targets, including moderate inhibitory activity against bacterial beta-carbonic anhydrases, antiviral activity against SARS-CoV-2, and transporter substrate behavior in studies with TP transporter and OCT transporters. Overall, Histamine is a potent and versatile bioactive compound with significant potential as a therapeutic agent influencing carbonic anhydrase activity, histamine receptor modulation, and cardiovascular effects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Histamine (Ergamine) is an amine derived by the enzymatic decarboxylation of histamine. Histamine is a potent stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a neurotransmitter of central action.
Targets&IC50	HEK293 cells:13 nM (EC50), CHO cells:640 nM (EC50), Sf9 cells:11 nM (EC50)
Synonyms	Ergamine

Chemical Properties

Molecular Weight	111.15
Formula	C₅H₉N₃
Cas No.	51-45-6
Smiles	NCCc1c[nH]cn1
Relative Density.	1.14g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 260 mg/mL (2339.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	8.9969 mL	44.9843 mL	89.9685 mL	449.8426 mL
5 mM	1.7994 mL	8.9969 mL	17.9937 mL	89.9685 mL
10 mM	0.8997 mL	4.4984 mL	8.9969 mL	44.9843 mL
20 mM	0.4498 mL	2.2492 mL	4.4984 mL	22.4921 mL
50 mM	0.1799 mL	0.8997 mL	1.7994 mL	8.9969 mL
100 mM	0.0900 mL	0.4498 mL	0.8997 mL	4.4984 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc