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CCT251455

Name: CCT251455
Brand: TargetMol
SKU: T14906
Rating: 4.5 (1 reviews)

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Catalog No. T14906Cas No. 1400284-80-1

Alias CCT 251455

CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.

CCT251455

😃Good

Purity: 99.1%

Catalog No. T14906Alias CCT 251455Cas No. 1400284-80-1

CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,820	8-10 weeks	8-10 weeks
50 mg	$2,380	8-10 weeks	8-10 weeks
100 mg	$3,100	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.1%

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COA

Product Introduction

Bioactivity

Description	CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.
Targets&IC50	MPS1:3 nM
In vitro	CCT251455 is a potent MPS1 inhibitor that exhibits high selectivity across a broad kinase profiling panel and excellent translation of in vitro biochemical potency to cellular potency compared to the isolated MPS1 enzyme (P-MPS1 IC50 of 0.04 μM and HCT116 GI50 of 0.16 μM).[1]
In vivo	Methods: Mice bearing HCT116 human colon cancer xenografts were treated with CCT251455 (50, 75, and 100 mg/kg, orally, twice daily). Results: CCT251455 was well tolerated at all doses and inhibited MPS1 activity in mice; the observed reduction in phospho-histone H3 inhibition was consistent with the reduction in total plasma and tumor tissue exposure measured in the same experiment. [1]
Synonyms	CCT 251455

Chemical Properties

Molecular Weight	503.98
Formula	C₂₆H₂₆ClN₇O₂
Cas No.	1400284-80-1
Smiles	O=C(OC(C)(C)C)N1C=2C=C(N=CC2C=C1C=3C=NN(C3)C)NC=4C=CC(=CC4Cl)C5=CN=CN5C
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (198.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (6.55 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9842 mL	9.9210 mL	19.8421 mL	99.2103 mL
5 mM	0.3968 mL	1.9842 mL	3.9684 mL	19.8421 mL
10 mM	0.1984 mL	0.9921 mL	1.9842 mL	9.9210 mL
20 mM	0.0992 mL	0.4961 mL	0.9921 mL	4.9605 mL
50 mM	0.0397 mL	0.1984 mL	0.3968 mL	1.9842 mL
100 mM	0.0198 mL	0.0992 mL	0.1984 mL	0.9921 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc