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SMER18

Name: SMER18
Brand: TargetMol
SKU: T16900
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16900Cas No. 944153-47-3

Alias SMER-18, SMER 18

SMER18 is a small molecule enhancer of rapamycin, functioning as an mTOR-independent autophagy inducer.

SMER18

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Purity: 97.27%

Catalog No. T16900Alias SMER-18, SMER 18Cas No. 944153-47-3

SMER18 is a small molecule enhancer of rapamycin, functioning as an mTOR-independent autophagy inducer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$81	In Stock	In Stock
5 mg	$208	In Stock	In Stock
10 mg	$298	In Stock	In Stock
25 mg	$577	In Stock	In Stock
50 mg	$893	In Stock	In Stock
100 mg	$1,180	-	In Stock
1 mL x 10 mM (in DMSO)	$227	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.27%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	SMER18 is a small molecule enhancer of rapamycin, functioning as an mTOR-independent autophagy inducer.
In vitro	SMER18 is a small molecule enhancer of rapamycin that functions as an mTOR-independent autophagy inducer, capable of enhancing the clearance of autophagy substrates such as mutant htt (related to Huntington's disease) and A53T α-synuclein (associated with familial Parkinson's disease)[1].
Synonyms	SMER-18, SMER 18

Chemical Properties

Molecular Weight	287.74
Formula	C₁₆H₁₄ClNO₂
Cas No.	944153-47-3
Smiles	C\C(Nc1cccc(O)c1)=C\C(=O)c1ccc(Cl)cc1
Relative Density.	1.298 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (278.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4754 mL	17.3768 mL	34.7536 mL	173.7680 mL
5 mM	0.6951 mL	3.4754 mL	6.9507 mL	34.7536 mL
10 mM	0.3475 mL	1.7377 mL	3.4754 mL	17.3768 mL
20 mM	0.1738 mL	0.8688 mL	1.7377 mL	8.6884 mL
50 mM	0.0695 mL	0.3475 mL	0.6951 mL	3.4754 mL
100 mM	0.0348 mL	0.1738 mL	0.3475 mL	1.7377 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc