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Guanylate cyclase

Guanylate cyclase (also known as guanyl cyclase, guanylyl cyclase, or GC) is a lyase enzyme that converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP) and pyrophosphate. It is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and inhibited by high intracellular calcium levels. In response to calcium levels, guanylate cyclase synthesizes cGMP from GTP. cGMP keeps cGMP-gated channels open, allowing for the entry of calcium into the cell.

  • Sinitrodil
    T34648143248-63-9In house
    Sinitrodil (ITF-296) is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris.
    • $142
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  • MCUF-651
    T677342747162-85-0
    MCUF-651 is a guanylyl cyclase A receptor positive allosteric modulators, EC50=0.45 μM.
    • $183
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  • LY83583
    T2157691300-60-6In house
    LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.
    • $55
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  • Glutaminyl Cyclase Inhibitor 1
    T114242110449-60-8In house
    Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.
    • $122
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    TargetMol | Inhibitor Sale
  • Cinaciguat
    T1984329773-35-5
    Cinaciguat (BAY 58-2667) (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensated heart failure.
    • $66
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    TargetMol | Citations Cited
  • Riociguat
    T6968625115-55-1
    Riociguat (BAY 632521) is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension.
    • $60
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    TargetMol | Citations Cited
  • Lificiguat
    T4381170632-47-0
    Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
    • $43
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    TargetMol | Citations Cited
  • Methylene Blue
    T688861-73-4
    Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
    • $30
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    TargetMol | Citations Cited
  • Indusatumab
    T767691497400-26-6
    Indusatumab (5F9 Monoclonal antibody) is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody that can be used to synthesize antibody-drug conjugate.
    • $178
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  • Runcaciguat
    T168081402936-61-1
    Runcaciguat is a soluble guanylate cyclase stimulator. Runcaciguat combines with selective partial adenosine A1 receptor agonists and can be used in studies about cardiovascular and renal diseases.
    • $58
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  • Nitroprusside disodium dihydrate
    T699113755-38-9
    Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood.
    • $45
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  • Praliciguat
    T165691628730-49-3
    Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator.
    • $153
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  • Nelociguat
    T7201625115-52-8
    Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway.
    • $31
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  • ODQ
    T1977741443-28-1
    ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.
    • $42
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  • BAY 41-8543
    T21712256498-66-5
    BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).
    • $40
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  • Plecanatide
    T9080467426-54-6
    Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.
    • $72
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  • Olinciguat
    T163831628732-62-6
    Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay.
    • $188
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  • Vericiguat
    T172261350653-20-1
    Vericiguat (BAY1021189) is a potent and orally available guanylate cyclase stimulator.
    • $40
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  • Methylene Blue trihydrate
    T00067220-79-3
    Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate is used as a bacteriologic stain and as an indicator. It inhibits soluble guanylyl cyclase and has been used to treat cyanide poisoning and to lower levels of methemoglobin. It also inhibits tau filament formation (IC50: 1.9μM).
    • $42
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  • Linaclotide
    T11852851199-59-2
    Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist.
    • $60
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  • Guanylin (mouse, rat)
    T80150145257-03-0
    Guanylin (mouse, rat), a peptide consisting of 15 amino acids, acts as an activator of intestinal guanylate cyclase and is utilized in diarrhea research [1].
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  • Uroguanylin (human)
    T80067154525-25-4
    Uroguanylin (human) serves as a natural ligand for the Guanylyl Cyclase C (GCC) receptor in metastatic colorectal cancer tumors and exhibits anti-tumor effects in an animal model of human colon cancer [1] [2].
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  • BAY 41-2272
    T6775256376-24-6
    BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
    • $30
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  • Ataciguat
    T21607254877-67-3
    Ataciguat (HMR-1766) (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.
    • $44
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  • NS-2028
    T16344204326-43-2
    NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used in the research of nitric oxide signaling pathways. NS-2028 inhibits soluble Guanylyl Cyclase
    • $55
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