Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

(Rac)-Rotigotine hydrochloride

😃Good
Catalog No. T12676Cas No. 102120-99-0

(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine, a full agonist of the dopamine receptor and a partial agonist of the 5-HT1A receptor.

(Rac)-Rotigotine hydrochloride
Other Forms of (Rac)-Rotigotine hydrochloride:

(Rac)-Rotigotine hydrochloride

😃Good
Catalog No. T12676Cas No. 102120-99-0
(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine, a full agonist of the dopamine receptor and a partial agonist of the 5-HT1A receptor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mL x 10 mM (in DMSO)$527-10 days7-10 days
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Resource Download

Product Introduction

Bioactivity
Description
(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine, a full agonist of the dopamine receptor and a partial agonist of the 5-HT1A receptor.
Targets&IC50
D1 receptor:83 nM (Ki), D3 receptor:0.71 nM (Ki), 5-HT2B receptor:27 nM (Ki), 5-HT1A receptor:30 nM (Ki), D2 receptor:13.5 nM (Ki), D4 receptor:3.9-15 nM (Ki), D5 receptor:5.4 nM (Ki)
In vitro
In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC50?respectively: 9.0, 9.4-8.6, 9.7)[1]. Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+?toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone[4]. .
Chemical Properties
Molecular Weight351.93
FormulaC19H26ClNOS
Cas No.102120-99-0
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (142.07 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (7.1 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8415 mL14.2074 mL28.4147 mL142.0737 mL
5 mM0.5683 mL2.8415 mL5.6829 mL28.4147 mL
10 mM0.2841 mL1.4207 mL2.8415 mL14.2074 mL
20 mM0.1421 mL0.7104 mL1.4207 mL7.1037 mL
50 mM0.0568 mL0.2841 mL0.5683 mL2.8415 mL
100 mM0.0284 mL0.1421 mL0.2841 mL1.4207 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Rotigotine HydrochlorideDopamineReceptorDopamine receptorDopamine Receptor(Rac)Rotigotine hydrochloride(Rac) Rotigotine hydrochloride
Related Tags: buy (Rac)-Rotigotine hydrochloride | purchase (Rac)-Rotigotine hydrochloride | (Rac)-Rotigotine hydrochloride cost | order (Rac)-Rotigotine hydrochloride | (Rac)-Rotigotine hydrochloride chemical structure | (Rac)-Rotigotine hydrochloride in vitro | (Rac)-Rotigotine hydrochloride formula | (Rac)-Rotigotine hydrochloride molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.