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ETC-159

Name: ETC-159
Brand: TargetMol
SKU: T4043
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T4043Cas No. 1638250-96-0

Alias ETC-1922159, ETC159, ETC 159

ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor that inhibits β-catenin reporter activity with an IC50 of 2.9 nM.

ETC-159

🥰Excellent

Purity: 99.30%

Catalog No. T4043Alias ETC-1922159, ETC159, ETC 159Cas No. 1638250-96-0

ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor that inhibits β-catenin reporter activity with an IC50 of 2.9 nM.

Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$68	In Stock
25 mg	$126	In Stock
50 mg	$207	In Stock
100 mg	$369	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Batch Information

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Purity:99.30%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor that inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
Targets&IC50	β-catenin:2.9 nM.
Synonyms	ETC-1922159, ETC159, ETC 159

Chemical Properties

Molecular Weight	391.38
Formula	C₁₉H₁₇N₇O₃
Cas No.	1638250-96-0
Smiles	Cn1c2ncn(CC(=O)Nc3ccc(nn3)-c3ccccc3)c2c(=O)n(C)c1=O
Relative Density.	1.47 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (140.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5551 mL	12.7753 mL	25.5506 mL	127.7531 mL
5 mM	0.5110 mL	2.5551 mL	5.1101 mL	25.5506 mL
10 mM	0.2555 mL	1.2775 mL	2.5551 mL	12.7753 mL
20 mM	0.1278 mL	0.6388 mL	1.2775 mL	6.3877 mL
50 mM	0.0511 mL	0.2555 mL	0.5110 mL	2.5551 mL
100 mM	0.0256 mL	0.1278 mL	0.2555 mL	1.2775 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc