GCGR Protein, Human, Recombinant (His & Avi)

Name: GCGR Protein, Human, Recombinant (His & Avi)
Brand: TargetMol
SKU: TMPK-01693
Rating: 4.5 (1 reviews)

(Synonyms: MVAH, Glucagon receptor, GL-R, GGR, GCGR) Copy Product Info

Synonyms: MVAH, Glucagon receptor, GL-R, GGR, GCGR

Catalog No. TMPK-01693 Copy Product Info

GCGR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 Cells. The accession number is P47871.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$74	7-10 days	7-10 days
10 µg	$113	7-10 days	7-10 days
20 µg	$175	7-10 days	7-10 days
50 µg	$316	7-10 days	7-10 days
100 µg	$490	7-10 days	7-10 days
200 µg	$793	7-10 days	7-10 days
500 µg	$1,470	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized Human GCGR, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-GCGR Antibody, hFc Tag with the EC50 of 3.6 ng/ml determined by ELISA (QC Test).
Description	GCGR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 Cells. The accession number is P47871.
Species	Human
Expression System	HEK293 Cells
Tag	C-His-Avi
Accession Number	P47871
Construction	Ala26-Lys136
Protein Purity	> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
Endotoxin	< 1 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	MVAH, Glucagon receptor, GL-R, GGR, GCGR
Research Background	The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed at the plasma membrane is constitutively ubiquitinated and upon agonist-activation, internalized GCGRs are deubiquitinated at early endosomes and recycled via Rab4-containing vesicles.

Chemical Properties

Molecular Weight

15.96 kDa (Predicted); 30-50 kDa (Reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.