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Xanomeline tartrate

🥰Excellent
Catalog No. T39010Cas No. 152854-19-8
Alias LY-246708 tartrate, LY246708 tartrate, LY 246708 tartrate

Xanomeline tartrate (LY 246708 tartrate) is an M1 and M4 mAChR agonist with antipsychotic-like activity that improves cognition and can be used in studies of schizophrenia and Alzheimer's disease.

Xanomeline tartrate
Other Forms of Xanomeline tartrate:

Xanomeline tartrate

🥰Excellent
Purity: 99.19%
Catalog No. T39010Alias LY-246708 tartrate, LY246708 tartrate, LY 246708 tartrateCas No. 152854-19-8
Xanomeline tartrate (LY 246708 tartrate) is an M1 and M4 mAChR agonist with antipsychotic-like activity that improves cognition and can be used in studies of schizophrenia and Alzheimer's disease.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$30In StockIn Stock
5 mg$46In StockIn Stock
10 mg$64In StockIn Stock
25 mg$98In StockIn Stock
50 mg$148In StockIn Stock
100 mg$217In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.19%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Xanomeline tartrate (LY 246708 tartrate) is an M1 and M4 mAChR agonist with antipsychotic-like activity that improves cognition and can be used in studies of schizophrenia and Alzheimer's disease.
In vitro
Xanomeline tartrate (LY 246708) (0.1-10 μM; CNS4U) shows an overall increase in average firing rate, indicating the functional presence of M1 receptors in hiPSC-derived neurons[1].
In vivo
In Male Cebus apella monkeys, Xanomeline tartrate ( 0.5-3 mg / kg ; s.c. ; 1-3 hours ) can induce salivation and vomiting in some monkeys[3].
SynonymsLY-246708 tartrate, LY246708 tartrate, LY 246708 tartrate
Chemical Properties
Molecular Weight431.5
FormulaC18H29N3O7S
Cas No.152854-19-8
SmilesO[C@@H]([C@H](O)C(O)=O)C(O)=O.CCCCCCOc1nsnc1C1=CCCN(C)C1
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200 mg/mL (463.5 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.59 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3175 mL11.5875 mL23.1750 mL115.8749 mL
5 mM0.4635 mL2.3175 mL4.6350 mL23.1750 mL
10 mM0.2317 mL1.1587 mL2.3175 mL11.5875 mL
20 mM0.1159 mL0.5794 mL1.1587 mL5.7937 mL
50 mM0.0463 mL0.2317 mL0.4635 mL2.3175 mL
100 mM0.0232 mL0.1159 mL0.2317 mL1.1587 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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