store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zharp2-1, a RIPK2 inhibitor, inhibits the transcription of inflammatory cytokines induced by MDP-induced or Listeria monocytogenes infection and alleviates MDP-induced peritonitis symptoms in mice, which can be used for the study of inflammatory bowel disease (IBD).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 62.00 | |
10 mg | In stock | $ 98.00 | |
25 mg | In stock | $ 196.00 | |
50 mg | In stock | $ 322.00 | |
100 mg | In stock | $ 513.00 |
Description | Zharp2-1, a RIPK2 inhibitor, inhibits the transcription of inflammatory cytokines induced by MDP-induced or Listeria monocytogenes infection and alleviates MDP-induced peritonitis symptoms in mice, which can be used for the study of inflammatory bowel disease (IBD). |
In vitro | iBMDM from mice were stimulated with 10 ng/mL IFN-γ and pre-treated with Zharp2-1 (IC50=6.4-17.4 nM) for 2 hours, followed by stimulation with 10 μg/mL MDP or 1 μg/mL L18-MDP for 12 hours. The results indicate that Zharp2-1 effectively blocks cytokine transcription and release in human and murine cells induced by MDP. [1]. |
In vivo | Treatment with Zharp2-1 (15 mg/kg, oral gavage, once daily, for 6 days) protects rats from DNBS-induced colon shortening and colon weight gain, indicating that Zharp2-1 therapy significantly improves colonic mucosal structural damage, muscle thickening, and inflammatory infiltration[1]. |
Molecular Weight | 383.4 |
Formula | C19H18N3O2PS |
CAS No. | 2772600-18-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2 mg/mL (5.22 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Zharp2-1 2772600-18-5 Apoptosis NF-Κb RIP kinase inhibitor inhibit