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Quorum Sensing-IN-3
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Catalog No. T78823Cas No. 5005-14-1
Alias QS-IN-1
Quorum Sensing-IN-3 (QS-IN-1) is a compound with inhibitory effects on bacterial community sensing, which inhibits the exchange of information between bacteria and inhibits biofilm formation.
Quorum Sensing-IN-3
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Purity: 99.58%
Catalog No. T78823Alias QS-IN-1Cas No. 5005-14-1
Quorum Sensing-IN-3 (QS-IN-1) is a compound with inhibitory effects on bacterial community sensing, which inhibits the exchange of information between bacteria and inhibits biofilm formation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $245 | In Stock | In Stock | |
| 5 mg | $679 | In Stock | In Stock | |
| 10 mg | $840 | In Stock | In Stock | |
| 25 mg | $1,110 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.58%
Appearance:Solid
Color:Yellow
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Product Introduction
Quorum Sensing-IN-3 AI Summary
Quorum Sensing-IN-3 demonstrates a broad range of bioactivities across various biological processes. It has shown potency in modulating miRNAs and activating promoters such as Rab9, SMN2, and NPC1. It also exhibits inhibitory effects on certain transcriptional activities, including ROR gamma and Menin-MLL interaction, and disrupts DNA repair and genotoxicity. Furthermore, Quorum Sensing-IN-3 has potential antiviral properties, inhibiting viral entry for Lassa Virus, Marburg Virus, and Hepatitis C Virus, as well as interacting with HIV-1 protein Vpr.
In cytotoxicity assays, Quorum Sensing-IN-3 shows an LD50 of greater than 30.0 umol/L against human THP1 cells. It demonstrates antimycobacterial activity with an IC90 of 533,000 nM against Mycobacterium kansasii CIT11/06, and variable antibacterial activity against Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus, with different IC80 values depending on the duration of exposure.
Quorum Sensing-IN-3 also has been tested for antifungal activity against several strains, including Trichophyton mentagrophytes, Trichosporon asahii, Candida krusei, and Candida albicans, showing differing degrees of effectiveness and IC values across various time points.
Moreover, Quorum Sensing-IN-3 exhibits intrinsic clearance rates in liver cells, with a clearance rate of 64.57 uL/min/(10^6cells)^-1 in rat hepatocytes, 77.62 uL/min/(10^6cells)^-1 in human hepatocytes, and greater than 150.0 mL/min.g^-1 in human liver microsomes. This suggests potential bioactivity related to hepatic clearance processes. Overall, these findings highlight the compound's diverse pharmacological profile..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Quorum Sensing-IN-3 (QS-IN-1) is a compound with inhibitory effects on bacterial community sensing, which inhibits the exchange of information between bacteria and inhibits biofilm formation. |
| Synonyms | QS-IN-1 |
| Molecular Weight | 254.31 |
| Formula | C14H10N2OS |
| Cas No. | 5005-14-1 |
| Smiles | O=C(NC1=NC=2C=CC=CC2S1)C=3C=CC=CC3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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