IL-21 Protein, Mouse, Recombinant

Catalog No. TMPY-02806

IL-21 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 14.3kDa and the accession number is Q9ES17.

IL-21 Protein, Mouse, Recombinant

Catalog No. TMPY-02806

IL-21 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 14.3kDa and the accession number is Q9ES17.

Pack Size	Price	Availability
5 μg	$98	7-10 days
10 μg	$166	7-10 days
20 μg	$275	In Stock
50 μg	$597	7-10 days
100 μg	$1,080	7-10 days
200 μg	$1,970	7-10 days
500 μg	$4,380	7-10 days
1 mg	$8,080	7-10 days

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COA User Guide of Recombinant Proteins

Product Information

Biological Activity	Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 10-65 ng/mL.
Description	IL-21 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 14.3kDa and the accession number is Q9ES17.
Species	Mouse
Expression System	E. coli
Tag	Tag Free
Accession Number	Q9ES17
Synonyms	interleukin 21,IL-21
Construction	A DNA sequence encoding the soluble form of mouse IL21 (Q9ES17) (Pro 25-Ser 146) was expressed, with an initial Met at the N-terminus. Predicted N terminal: Met
Protein Purity	≥ 95 % as determined by SDS-PAGE
Molecular Weight	14.3kDa (predicted); 15 kDa (reducing conditions)
Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy