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Anti-CBARA1/MICU1 Antibody (4K284)
😃Good
Catalog No. TMAB-03708
Anti-CBARA1/MICU1 Antibody (4K284) is a Mouse antibody targeting CBARA1/MICU1. Anti-CBARA1/MICU1 Antibody (4K284) can be used in WB.
Anti-CBARA1/MICU1 Antibody (4K284)
Anti-CBARA1/MICU1 Antibody (4K284)
😃Good
Catalog No. TMAB-03708
Anti-CBARA1/MICU1 Antibody (4K284) is a Mouse antibody targeting CBARA1/MICU1. Anti-CBARA1/MICU1 Antibody (4K284) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 200 μg | $1,058 | 7-10 days | 7-10 days | |
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CBARA1/MICU1 Antibody (4K284) is a Mouse antibody targeting CBARA1/MICU1. Anti-CBARA1/MICU1 Antibody (4K284) can be used in WB. |
| Ig Type | IgG |
| Clone | 4K284 |
| Reactivity | Human (predicted:Mouse,Rat) |
| Application | |
| Recommended Dose | WB: 1:500-1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Mitochondrion inner membrane; Single-pass membrane protein; Mitochondrion intermembrane space |
| Tissue Specificity | Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013] |
| Immunogen | Recombinant Protein: human CBARA1 Protein (1-250/476) |
| Antigen Species | Human |
| Gene Name | MICU1 |
| Gene ID | |
| Protein Name | Calcium uptake protein 1, mitochondrial |
| Uniprot ID | |
| Function | Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733). |
| Molecular Weight | Theoretical: 54 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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