IL-1RA Protein, Human, Recombinant (HEK293)

Name: IL-1RA Protein, Human, Recombinant (HEK293)
Brand: TargetMol
SKU: TMPS-00056
Rating: 4.5 (1 reviews)

(Synonyms: IRAP, IL-1RN, IL1RA, ICIL-1RA) Copy Product Info

Synonyms: IRAP, IL-1RN, IL1RA, ICIL-1RA

Catalog No. TMPS-00056 Copy Product Info

IL-1RA Protein, Human, Recombinant (HEK293) is expressed in HEK293 Cells. The accession number is P18510.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$54	7-10 days	7-10 days
10 µg	$85	7-10 days	7-10 days
20 µg	$113	7-10 days	7-10 days
50 µg	$170	7-10 days	7-10 days
100 µg	$286	7-10 days	7-10 days
200 µg	$485	7-10 days	7-10 days
500 µg	$985	7-10 days	7-10 days
1 mg	$1,690	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	ED 50 < 0.1 μg /ml, measured in a neutralization assay using D10S cells in the presence of 50.0 pg/ml Human IL-1a.
Description	IL-1RA Protein, Human, Recombinant (HEK293) is expressed in HEK293 Cells. The accession number is P18510.
Species	Human
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	P18510
Construction	Arg26-Glu177
Protein Purity	> 95% as determined by SDS-PAGE; > 95% as determined by HPLC
Endotoxin	< 0.2 EU/μg of protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	IRAP, IL-1RN, IL1RA, ICIL-1RA
Research Background	IL-1 Receptor Antagonist, also known as IL-1RA, ICIL-1RA, IRAP and IL-1RN, is a member of the interleukin 1 cytokine family. It is expressed by monocytes, neutrophils, macrophages, epithelial cells and fibroblasts. IL-1RA inhibits the activity of both IL-1alpha and IL-1beta, and modulates a variety of IL-1 related immune and inflammatory responses. It inhibits the activity of IL-1 by binding to the receptor IL-1R1 and preventing its association with the coreceptor IL-1RAP for signaling. Clinical studies are being conducted to investigate the use of IL-1RA in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia.

Chemical Properties

Molecular Weight

18~23 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.