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Anti-Renalase Antibody (2K659)

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Catalog No. TMAB-12187

Anti-Renalase Antibody (2K659) is a Rabbit antibody targeting Renalase. Anti-Renalase Antibody (2K659) can be used in WB,IHC-P,IHC-Fr,IF.

Anti-Renalase Antibody (2K659)

Anti-Renalase Antibody (2K659)

😃Good
Catalog No. TMAB-12187
Anti-Renalase Antibody (2K659) is a Rabbit antibody targeting Renalase. Anti-Renalase Antibody (2K659) can be used in WB,IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1497-10 days7-10 days
50 μL$2637-10 days7-10 days
100 μL$4727-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Renalase Antibody (2K659) is a Rabbit antibody targeting Renalase. Anti-Renalase Antibody (2K659) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
Clone
2K659
Reactivity
Human,Mouse,Rat
Application
WB
IHC-P
IHC-Fr
IF
Recommended Dose
WB: 1:1000-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; IF: 1:100-200
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted.
Tissue SpecificitySecreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundRenalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney.
Antigen Details
Immunogen
A synthesized peptide: human Renalase
Antigen Species
Human
Gene Name
RNLS
Gene ID
55328
Protein Name
Renalase
Uniprot ID
Q5VYX0
Function
Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity.
Chemical Properties
Molecular WeightTheoretical: 38 kDa. Actual: 42 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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