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TRAIL R3/TNFRSF10C Protein, Human, Recombinant (hFc & His)

Catalog No. TMPJ-00418
Synonyms: Decoy Receptor 1, Antagonist Decoy Receptor for TRAIL/Apo-2L, DcR1, Tumor Necrosis Factor Receptor Superfamily Member 10C, Lymphocyte Inhibitor of TRAIL, TNF-Related Apoptosis-Inducing Ligand Receptor 3, Decoy TRAIL Receptor Without Death Domain, TRAIL Re

Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains, lacks the intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
TRAIL R3/TNFRSF10C Protein, Human, Recombinant (hFc & His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 60.00
50 μg 5 days $ 184.00
500 μg 5 days $ 806.00
1 mg 5 days $ 1,060.00
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Biological Description
Technical Params
Product Properties
Description Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains, lacks the intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.
Species Human
Expression System Human Cells
Tag C-Fc-6His
Accession Number O14798
Synonyms Decoy Receptor 1, Antagonist Decoy Receptor for TRAIL/Apo-2L, DcR1, Tumor Necrosis Factor Receptor Superfamily Member 10C, Lymphocyte Inhibitor of TRAIL, TNF-Related Apoptosis-Inducing Ligand Receptor 3, Decoy TRAIL Receptor Without Death Domain, TRAIL Re
Amino Acid Ala26-Ala221
Construction Recombinant Human TNF-Related Apoptosis-Inducing Ligand Receptor 3 is produced by our Mammalian expression system and the target gene encoding Ala26-Ala221 is expressed with a human IgG1 Fc, 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 90 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains, lacks the intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.

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Keywords

TRAIL R3/TNFRSF10C Protein, Human, Recombinant (hFc & His) Decoy Receptor 1 Antagonist Decoy Receptor for TRAIL/Apo-2L DcR1 Tumor Necrosis Factor Receptor Superfamily Member 10C Lymphocyte Inhibitor of TRAIL TNF-Related Apoptosis-Inducing Ligand Receptor 3 Decoy TRAIL Receptor Without Death Domain TRAIL Re recombinant recombinant-proteins proteins protein

 

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