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Anti-hUPF1 Antibody (6P759)
😃Good
Catalog No. TMAB-07455
Anti-hUPF1 Antibody (6P759) is a Rabbit antibody targeting hUPF1. Anti-hUPF1 Antibody (6P759) can be used in IP,FCM,ICC/IF.
Anti-hUPF1 Antibody (6P759)
Anti-hUPF1 Antibody (6P759)
😃Good
Catalog No. TMAB-07455
Anti-hUPF1 Antibody (6P759) is a Rabbit antibody targeting hUPF1. Anti-hUPF1 Antibody (6P759) can be used in IP,FCM,ICC/IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $150 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $471 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-hUPF1 Antibody (6P759) is a Rabbit antibody targeting hUPF1. Anti-hUPF1 Antibody (6P759) can be used in IP,FCM,ICC/IF. |
| Ig Type | IgG |
| Clone | 6P759 |
| Reactivity | Human (predicted:Mouse) |
| Application | |
| Recommended Dose | IP: 1:10-50; FCM: 1μg/Test; ICC/IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cytoplasm, P-body. Note=Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm. |
| Tissue Specificity | Ubiquitous. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | In eukaryotes, it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1, a mammalian ortholog of Upflp, is essential for embryonic viability (1–3). Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain, NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase. |
| Immunogen | A synthesized peptide: human Regulator of nonsense transcripts 1 |
| Antigen Species | Human |
| Gene Name | UPF1 |
| Gene ID | |
| Protein Name | Regulator of nonsense transcripts 1 |
| Function | Plays a role in replication-dependent histone mRNA degradation at the end of phase S. Part of a post-splicing multiprotein complex. Involved in nonsense-mediated decay (NMD) as part of the SMG1C complex, a mRNA surveillance complex that recognizes and degrades mRNAs containing premature translation termination codons (PTCs). The complex probably acts by associating with ribosomes during tranlation termination on mRNPs. If an exon junction complex (EJC) is located 50-55 or more nucleotides downstream from the termination codon, RENT1 is phosphorylated by SMG1, triggering nonsense-mediated decay (NMD). Essential for embryonic viability. |
| Molecular Weight | Theoretical: 124 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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