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Tolrestat

Name: Tolrestat
Brand: TargetMol
SKU: T17114
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17114Cas No. 82964-04-3

Alias AY-27773

Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM).

Tolrestat

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Purity: 98.89%

Catalog No. T17114Alias AY-27773Cas No. 82964-04-3

Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM).

Pack Size	Price	Availability
1 mg	$40	In Stock
5 mg	$93	In Stock
10 mg	$156	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.89%

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COA HPLC HNMR FNMR

Product Introduction

Bioactivity

Description	Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM).
Targets&IC50	Aldose reductase:35 nM
In vivo	The estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil, respectively in diabetic rats[1]. Tolrestat inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice[2]. Tolrestat (1.8 mg/kg) causes a reversal of normal RBC sorbitol levels[3].
Synonyms	AY-27773

Chemical Properties

Molecular Weight	357.35
Formula	C₁₆H₁₄F₃NO₃S
Cas No.	82964-04-3
Smiles	C(N(CC(O)=O)C)(=S)C=1C2=C(C(C(F)(F)F)=C(OC)C=C2)C=CC1
Relative Density.	1.399 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (279.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7984 mL	13.9919 mL	27.9838 mL	139.9188 mL
5 mM	0.5597 mL	2.7984 mL	5.5968 mL	27.9838 mL
10 mM	0.2798 mL	1.3992 mL	2.7984 mL	13.9919 mL
20 mM	0.1399 mL	0.6996 mL	1.3992 mL	6.9959 mL
50 mM	0.0560 mL	0.2798 mL	0.5597 mL	2.7984 mL
100 mM	0.0280 mL	0.1399 mL	0.2798 mL	1.3992 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc