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ICI 174,864

😃Good
Catalog No. TP2013Cas No. 89352-67-0

Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.

ICI 174,864

ICI 174,864

😃Good
Catalog No. TP2013Cas No. 89352-67-0
Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$71335 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.
Chemical Properties
Molecular Weight691.87
FormulaC38H53N5O7
Cas No.89352-67-0
Smiles[C@H](N(CC=C)CC=C)(CC1=CC=C(O)C=C1)C(NC(C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)(C)C)=O
Relative Density.1.16 g/cm3
Sequence{N,N-diallyl}-Tyr-{Aib}-Phe-Leu
Sequence Short{N,N-diallyl}-Y-{Aib}-FL
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 1 mg/mL (1.45 mM), Sonication is recommended.
DMSO: 69.19 mg/mL (100 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.4454 mL7.2268 mL14.4536 mL72.2679 mL
DMSO
1mg5mg10mg50mg
5 mM0.2891 mL1.4454 mL2.8907 mL14.4536 mL
10 mM0.1445 mL0.7227 mL1.4454 mL7.2268 mL
20 mM0.0723 mL0.3613 mL0.7227 mL3.6134 mL
50 mM0.0289 mL0.1445 mL0.2891 mL1.4454 mL
100 mM0.0145 mL0.0723 mL0.1445 mL0.7227 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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