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SB399885

Name: SB399885
Brand: TargetMol
SKU: T19669
Price: 62 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19669Cas No. 402713-80-8

Alias SB399885 Hydrochloride, SB-399885, SB399885, SB 399885

SB399885 (SB 399885) is an effective, brain penetrant, and orally active antagonist of SR-6. It shows 200-fold selectivity for SR-6 over other serotonin receptors (pKi: 9.11, 8.81, and 9.02 for human recombinant, native rat, and native human SR-6 receptors, respectively).

SB399885

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Purity: 98.94%

Catalog No. T19669Alias SB399885 Hydrochloride, SB-399885, SB399885, SB 399885Cas No. 402713-80-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$62	In Stock	In Stock
5 mg	$125	In Stock	In Stock
10 mg	$186	In Stock	In Stock
25 mg	$307	In Stock	In Stock
50 mg	$413	In Stock	In Stock
100 mg	$583	-	In Stock
200 mg	$783	-	In Stock
1 mL x 10 mM (in DMSO)	$153	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.94%

Appearance:Solid

Color:White

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COA HPLC HNMR LCMS

Product Introduction

SB399885 AI Summary

SB399885 is a highly selective and potent antagonist for the human recombinant 5-HT6 receptor. It exhibits high binding affinity with a Ki value ranging between 0.7 and 0.7762 nM, and a Kb value of 0.25 nM. The compound demonstrates exceptional selectivity for the 5-HT6 receptor over various other serotonin and dopamine receptors, with selectivity ratios exceeding 200. Additionally, SB399885 shows bioactivity by inhibiting serotonin-induced increases in cAMP levels, suggesting potential therapeutic applications in modulating 5-HT6 receptor-related conditions. Beyond its neurological implications, SB399885 also displays antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells. Furthermore, the compound shows an ability to inhibit the SARS-CoV-2 3CL-Pro protease by 28.93% at a concentration of 20 μM, and displays inhibitory activity against the human HDAC6 enzyme. These diverse bioactivities highlight the compound’s multi-faceted therapeutic potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SB399885 (SB 399885) is an effective, brain penetrant, and orally active antagonist of SR-6. It shows 200-fold selectivity for SR-6 over other serotonin receptors (pKi: 9.11, 8.81, and 9.02 for human recombinant, native rat, and native human SR-6 receptors, respectively).
Targets&IC50	SR6 (native human):9.02 (pKi), SR6 (native rat):8.81 (pKi), SR6 (human recombinant):9.11 (pKi)
Synonyms	SB399885 Hydrochloride, SB-399885, SB399885, SB 399885

Chemical Properties

Molecular Weight	446.35
Formula	C₁₈H₂₁Cl₂N₃O₄S
Cas No.	402713-80-8
Smiles	O(C)C1=C(C=C(S(NC2=C(OC)C(Cl)=CC(Cl)=C2)(=O)=O)C=C1)N3CCNCC3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (123.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2404 mL	11.2020 mL	22.4039 mL	112.0197 mL
5 mM	0.4481 mL	2.2404 mL	4.4808 mL	22.4039 mL
10 mM	0.2240 mL	1.1202 mL	2.2404 mL	11.2020 mL
20 mM	0.1120 mL	0.5601 mL	1.1202 mL	5.6010 mL
50 mM	0.0448 mL	0.2240 mL	0.4481 mL	2.2404 mL
100 mM	0.0224 mL	0.1120 mL	0.2240 mL	1.1202 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc