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DU-14 (PTP1B/TC-PTP PROTAC)

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Catalog No. T203548Cas No. 3053413-58-1

DU-14 (PTP1B/TC-PTPPROTAC) is a potent and selective dual PROTAC degrader for PTP1B and TC-PTP, exhibiting IC50 values of 24.2 nM and 30.1 nM for the phosphatase activity of PTP1B and TC-PTP, respectively. It enhances IFN-γ signaling, promotes T cell activation, and possesses antitumor activity.

DU-14 (PTP1B/TC-PTP PROTAC)

DU-14 (PTP1B/TC-PTP PROTAC)

😃Good
Catalog No. T203548Cas No. 3053413-58-1
DU-14 (PTP1B/TC-PTPPROTAC) is a potent and selective dual PROTAC degrader for PTP1B and TC-PTP, exhibiting IC50 values of 24.2 nM and 30.1 nM for the phosphatase activity of PTP1B and TC-PTP, respectively. It enhances IFN-γ signaling, promotes T cell activation, and possesses antitumor activity.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
DU-14 (PTP1B/TC-PTPPROTAC) is a potent and selective dual PROTAC degrader for PTP1B and TC-PTP, exhibiting IC50 values of 24.2 nM and 30.1 nM for the phosphatase activity of PTP1B and TC-PTP, respectively. It enhances IFN-γ signaling, promotes T cell activation, and possesses antitumor activity.
In vitro
DU-14 (PTP1B/TC-PTP PROTAC) (0-1000 nM; 16 hours) induces degradation of PTP1B/TC-PTP and enhances STAT1 phosphorylation in IFN-γ-treated MC38 cells.
In vivo
In a mouse model of colon cancer, DU-14 (PTP1B/TC-PTP PROTAC) demonstrates antitumor activity when administered via intraperitoneal injection at a dosage of 25-50 mg/kg over 10 days.
Chemical Properties
Molecular Weight1505.46
FormulaC74H85BrF2N9O14PS
Cas No.3053413-58-1
SmilesC([C@@H](NC(CC1=CC(CNC([C@@H](NC([C@H](CC2=CC=C(C(P(=O)(O)O)(F)F)C=C2)NC([C@H](CC3=CC=CC=C3)NC(CC4=CC(OC)=C(O)C=C4)=O)=O)=O)CCCCNC(=O)C5=CC(Br)=C(C)C=C5)=O)=CC=C1)=O)C(C)(C)C)(=O)N6[C@H](C(N[C@@H](C)C7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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