Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R. Notably, AD186 completely reverses the antiallodynic effect of BD-1063 [1].
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Description | AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R. Notably, AD186 completely reverses the antiallodynic effect of BD-1063 [1]. |
Targets&IC50 | Sigma 1 Receptor:2.7 nM (Ki), Sigma 2 Receptor:27 nM (Ki) |
In vivo | AD186 (compound 4b) at dosages of 2.5-10 mg/kg administered subcutaneously (s.c.) completely reversed the antihyperalgesic effect of BD-1063 in capsaicin-induced mechanical hypersensitivity in mice [1]. |
Molecular Weight | 320.47 |
Formula | C22H28N2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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AD186 GPCR/G Protein Sigma receptor inhibitor inhibit