TREM-2 Protein, Mouse, Recombinant (His) V2

Name: TREM-2 Protein, Mouse, Recombinant (His) V2
Brand: TargetMol
SKU: TMPY-01703U
Rating: 4.5 (1 reviews)

(Synonyms: triggering receptor expressed on myeloid cells 2, Trem2c, Trem2b, Trem2a, TREM-2) Copy Product Info

Synonyms: triggering receptor expressed on myeloid cells 2, Trem2c, Trem2b, Trem2a, TREM-2

Catalog No. TMPY-01703U Copy Product Info

TREM-2 Protein, Mouse, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is Q99NH8-1.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$48	7-10 days	7-10 days
10 µg	$75	7-10 days	7-10 days
20 µg	$118	7-10 days	7-10 days
50 µg	$229	7-10 days	7-10 days
100 µg	$386	7-10 days	7-10 days
200 µg	$682	7-10 days	7-10 days
500 µg	$1,430	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized Mouse TREM2, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-TREM2 Antibody, hFc Tag with the EC50 of 2.5 ng/ml determined by ELISA.
Description	TREM-2 Protein, Mouse, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is Q99NH8-1.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q99NH8-1
Construction	Leu19-Ser171
Protein Purity	> 95% as determined by Tris-Bis PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	triggering receptor expressed on myeloid cells 2, Trem2c, Trem2b, Trem2a, TREM-2
Research Background	TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.

Chemical Properties

Molecular Weight

17.9 kDa (Predicted); 35-45 kDa (Due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.