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SB 206553 hydrochloride

Name: SB 206553 hydrochloride
Brand: TargetMol
SKU: T23314
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23314Cas No. 1197334-04-5

Alias SB206553 hydrochloride

SB 206553 hydrochloride is an orally active, selective, and efficient 5-HT2C inverse agonist and 5-HT2C/5-HT2B receptor antagonist with anti-anxiety activity. It is useful in neurological disease research.

SB 206553 hydrochloride

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Purity: 99.56%

Catalog No. T23314Alias SB206553 hydrochlorideCas No. 1197334-04-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	-	In Stock
5 mg	$123	-	In Stock
10 mg	$197	-	In Stock
25 mg	$396	-	In Stock
50 mg	$579	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.56%

Appearance:Solid

Color:Yellow

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	SB 206553 hydrochloride is an orally active, selective, and efficient 5-HT2C inverse agonist and 5-HT2C/5-HT2B receptor antagonist with anti-anxiety activity. It is useful in neurological disease research.
In vitro	SB 206553 hydrochloride (50 μM) prevented the promotion of mEPSC induced by the application of α-Me-5HT (10 μM), while the rise and decay time constants of mEPSC administered by α-Me-5HT remained unchanged in the presence of SB 206553 hydrochloride. [1]
In vivo	Intraperitoneal administration of SB 206553 hydrochloride (1-10 mg/kg) caused a dose-dependent increase in DA release from the accumbens and striatum in rats. [2] SB 206553 hydrochloride (1-10mg/kg), only 10mg/kg, enhanced c-Fos expression in STN, striatum (except dorsomedial part), NAcc, inner surface nucleus, substantia nigra reticularis (SNr) and densa (SNc), and ventral tegmental area. [3]
Synonyms	SB206553 hydrochloride

Chemical Properties

Molecular Weight	328.8
Formula	C₁₇H₁₇ClN₄O
Cas No.	1197334-04-5
Smiles	Cl.O=C(NC=1C=NC=CC1)N2C3=CC=4C=CN(C4C=C3CC2)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (76.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0414 mL	15.2068 mL	30.4136 mL	152.0681 mL
5 mM	0.6083 mL	3.0414 mL	6.0827 mL	30.4136 mL
10 mM	0.3041 mL	1.5207 mL	3.0414 mL	15.2068 mL
20 mM	0.1521 mL	0.7603 mL	1.5207 mL	7.6034 mL
50 mM	0.0608 mL	0.3041 mL	0.6083 mL	3.0414 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc