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Anti-Siglec-3/CD33 Antibody (7L591)
🥰Excellent
Catalog No. TMAY-02292
Anti-Siglec-3/CD33 Antibody (7L591) is a Rabbit antibody targeting Siglec-3/CD33. Anti-Siglec-3/CD33 Antibody (7L591) can be used in ELISA,FCM.
Anti-Siglec-3/CD33 Antibody (7L591)
Anti-Siglec-3/CD33 Antibody (7L591)
🥰Excellent
Catalog No. TMAY-02292
Anti-Siglec-3/CD33 Antibody (7L591) is a Rabbit antibody targeting Siglec-3/CD33. Anti-Siglec-3/CD33 Antibody (7L591) can be used in ELISA,FCM.
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Chemical Properties
| Description | Anti-Siglec-3/CD33 Antibody (7L591) is a Rabbit antibody targeting Siglec-3/CD33. Anti-Siglec-3/CD33 Antibody (7L591) can be used in ELISA,FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 7L591 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD33 expression on human whole blood monocytes. Cells were stained with purified anti-Human CD33, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable monocytes. |
| Application | ELISA,FCM |
| Recommended Dose | ELISA: 1:5000-1:10000; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD33 / Siglec-3 (rh CD33 / Siglec-3; TMPY-03805; AAH28152.1; Met1-His259). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Others Formats | APC/PerCP/FITC/PE |
| Antibody Types Available | 5 |
| Immunogen | Recombinant Human CD33 / Siglec-3 Protein (TMPY-03805) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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