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Anti-Siglec-3/CD33 Antibody (7L591)

😃Good
Catalog No. TMAY-02292
Alias Siglec-3, SIGLEC3, p67, CD33 molecule

Anti-Siglec-3/CD33 Antibody (7L591) is a Rabbit antibody targeting Siglec-3/CD33. Anti-Siglec-3/CD33 Antibody (7L591) can be used in ELISA,FCM.

Anti-Siglec-3/CD33 Antibody (7L591)

Anti-Siglec-3/CD33 Antibody (7L591)

😃Good
Catalog No. TMAY-02292Alias Siglec-3, SIGLEC3, p67, CD33 molecule
Anti-Siglec-3/CD33 Antibody (7L591) is a Rabbit antibody targeting Siglec-3/CD33. Anti-Siglec-3/CD33 Antibody (7L591) can be used in ELISA,FCM.
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100 μL$268 7-10 days
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Instruction Manual of Detection Antibody
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Product Introduction

Bioactivity
Description
Antibody Type: Rabbit Monoclonal

Application: ELISA, FCM

Reactivity: Human
AliasSiglec-3, SIGLEC3, p67, CD33 molecule
Ig Type
Rabbit IgG
Clone
7L591
Reactivity
Human
Verified Activity
Flow cytometric analysis of Human CD33 expression on human whole blood monocytes. Cells were stained with purified anti-Human CD33, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable monocytes.
Application
ELISA,FCM
Recommended Dose
ELISA: 1:5000-1:10000; FCM: 1:25-1:100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human CD33 / Siglec-3 (rh CD33 / Siglec-3; TMPY-03805; AAH28152.1; Met1-His259).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundMyeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
APC/PerCP/FITC/PE
Antibody Types Available
5
Antigen Details
Immunogen
Recombinant Protein: Human CD33 / Siglec-3 Protein (TMPY-03805)
Antigen Species
Human
Biology Area
Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SIGLEC 3
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