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L-Cysteinesulfinic acid

Name: L-Cysteinesulfinic acid
Brand: TargetMol
SKU: T11803
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11803Cas No. 1115-65-7

L-Cysteinesulfinic acid is an endogenous neurotransmitter with agonistic effects on a variety of metabotropic glutamate receptors (mGluRs), including mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, with a pEC50 = 2.7 to 4.0. L- Cysteinesulfinic acid is a pld-coupled agonist of metabotropic excitatory amino acid (EAA) receptors.

L-Cysteinesulfinic acid

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Purity: 99.96%

Catalog No. T11803Cas No. 1115-65-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$143	In Stock	In Stock
100 mg	$209	-	In Stock
200 mg	$313	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.96%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	L-Cysteinesulfinic acid is an endogenous neurotransmitter with agonistic effects on a variety of metabotropic glutamate receptors (mGluRs), including mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, with a pEC50 = 2.7 to 4.0. L- Cysteinesulfinic acid is a pld-coupled agonist of metabotropic excitatory amino acid (EAA) receptors.
Targets&IC50	mGluR2:3.9 (pEC50), mGluR6:4.0 (pEC50), mGluR5:4.6 (pEC50), mGluR8:3.94 (pEC50), mGluR4:2.7 (pEC50), mGluR1:3.92 (pEC50)
In vitro	CHO cells expressing mGluR1, mGluR5, and mGluR8 were treated with L-Cysteinesulfinic acid (L-CSA) for 45 minutes at 37°C, and receptor activation was assessed by measuring [³H]-inositol phosphate accumulation. The results showed that L-CSA activated mGluR1 and mGluR5, inducing IP formation with lower potency than L-glutamate but with significant activity. In cells expressing mGluR2, mGluR4, and mGluR6, L-CSA inhibited forskolin-induced cAMP production, indicating activation of these Gi/o-coupled receptors via inhibition of adenylyl cyclase [1].

Chemical Properties

Molecular Weight	153.16
Formula	C₃H₇NO₄S
Cas No.	1115-65-7
Smiles	[C@H](CS(=O)O)(C(O)=O)N
Relative Density.	1.828 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 110 mg/mL (718.2 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	6.5291 mL	32.6456 mL	65.2912 mL	326.4560 mL
5 mM	1.3058 mL	6.5291 mL	13.0582 mL	65.2912 mL
10 mM	0.6529 mL	3.2646 mL	6.5291 mL	32.6456 mL
20 mM	0.3265 mL	1.6323 mL	3.2646 mL	16.3228 mL
50 mM	0.1306 mL	0.6529 mL	1.3058 mL	6.5291 mL
100 mM	0.0653 mL	0.3265 mL	0.6529 mL	3.2646 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc