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L-Cysteinesulfinic acid is an endogenous neurotransmitter with agonistic effects on a variety of metabotropic glutamate receptors (mGluRs), including mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, with a pEC50 = 2.7 to 4.0. L- Cysteinesulfinic acid is a pld-coupled agonist of metabotropic excitatory amino acid (EAA) receptors.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $33 | In Stock | |
5 mg | $68 | In Stock | |
10 mg | $97 | In Stock | |
25 mg | $159 | In Stock | |
50 mg | $233 | In Stock | |
100 mg | $345 | In Stock | |
200 mg | $513 | In Stock |
Description | L-Cysteinesulfinic acid is an endogenous neurotransmitter with agonistic effects on a variety of metabotropic glutamate receptors (mGluRs), including mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, with a pEC50 = 2.7 to 4.0. L- Cysteinesulfinic acid is a pld-coupled agonist of metabotropic excitatory amino acid (EAA) receptors. |
Targets&IC50 | mGluR4:2.7 (pEC50), mGluR1:3.92 (pEC50), mGluR6:4.0 (pEC50), mGluR2:3.9 (pEC50), mGluR5:4.6 (pEC50), mGluR8:3.94 (pEC50) |
In vitro | CHO cells expressing mGluR1, mGluR5, and mGluR8 were treated with L-Cysteinesulfinic acid (L-CSA) for 45 minutes at 37°C, and receptor activation was assessed by measuring [³H]-inositol phosphate accumulation. The results showed that L-CSA activated mGluR1 and mGluR5, inducing IP formation with lower potency than L-glutamate but with significant activity. In cells expressing mGluR2, mGluR4, and mGluR6, L-CSA inhibited forskolin-induced cAMP production, indicating activation of these Gi/o-coupled receptors via inhibition of adenylyl cyclase [1]. |
Molecular Weight | 153.16 |
Formula | C3H7NO4S |
Cas No. | 1115-65-7 |
Smiles | [C@H](CS(=O)O)(C(O)=O)N |
Relative Density. | 1.828 g/cm3 (Predicted) |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 110 mg/mL (718.2 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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