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Soraprazan

Name: Soraprazan
Brand: TargetMol
SKU: T12977
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12977Cas No. 261944-46-1

Alias BYK61359, BYK 61359

Soraprazan (BYK61359) is a selective potassium channel inhibitor that inhibits gastric acid secretion and ameliorates age-related eye disease by removing lipofuscin from retinal pigment epithelial (RPE) cells.

Soraprazan

🥰Excellent

Purity: 99.84%

Catalog No. T12977Alias BYK61359, BYK 61359Cas No. 261944-46-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$147	In Stock	In Stock
2 mg	$236	In Stock	In Stock
5 mg	$446	In Stock	In Stock
10 mg	$745	In Stock	In Stock
25 mg	$1,150	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$359	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.84%

ee:99.06%

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	Soraprazan (BYK61359) is a selective potassium channel inhibitor that inhibits gastric acid secretion and ameliorates age-related eye disease by removing lipofuscin from retinal pigment epithelial (RPE) cells.
Targets&IC50	1 mM potassium ions (ion-loss vesicles):0.1 μM, [14C]-AP:0.19 μM
In vitro	Soraprazan is a potent inhibitor of gastric H,K-ATPase, with an IC50 value of 0.1 μM in the presence of 1 mM potassium ions in ion-loss vesicles, and inhibits dibutyryl cyclic AMP-stimulated [14C]AP accumulation in isolated gastric glands with an IC50 value of 0.19 μM. [1]
In vivo	Soraprazan 1-27 μmol/kg administered orally showed rapid and stable inhibition of acid secretion in dogs.[1]
Synonyms	BYK61359, BYK 61359

Chemical Properties

Molecular Weight	367.44
Formula	C₂₁H₂₅N₃O₃
Cas No.	261944-46-1
Smiles	O(CCOC)[C@@H]1C2=C(C=3N(C=C2)C(C)=C(C)N3)N[C@@H]([C@H]1O)C4=CC=CC=C4
Relative Density.	1.29 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (217.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7215 mL	13.6077 mL	27.2153 mL	136.0766 mL
5 mM	0.5443 mL	2.7215 mL	5.4431 mL	27.2153 mL
10 mM	0.2722 mL	1.3608 mL	2.7215 mL	13.6077 mL
20 mM	0.1361 mL	0.6804 mL	1.3608 mL	6.8038 mL
50 mM	0.0544 mL	0.2722 mL	0.5443 mL	2.7215 mL
100 mM	0.0272 mL	0.1361 mL	0.2722 mL	1.3608 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc