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KN-93 hydrochloride

Catalog No. T21557 CAS 1956426-56-4

KN-93 hydrochloride is a cell-permeable, reversible and competitive calmodulin-dependent kinase type II ( CaMKII ) inhibitor with a K i of 370 nM.

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KN-93 hydrochloride, CAS 1956426-56-4

Pack Size	Availability	Price/USD	Quantity
2 mg	5 days	$ 82.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

KN-93 hydrochloride is a cell-permeable, reversible and competitive calmodulin-dependent kinase type II ( CaMKII ) inhibitor with a K i of 370 nM.

In vitro

Following a 2-day treatment with KN-93, 95% of cells experienced G1 arrest, which was found to be reversible as cells began to progress into S and G2-M phases 1 day post-release of KN-93. Additionally, KN-93 effectively inhibits the growth of NIH 3T3 fibroblasts stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor. Furthermore, KN-93 demonstrates the ability to inhibit H+, K+-ATPase activity, significantly dissipate proton gradients across gastric membrane vesicles, and decrease luminal space volume. At a concentration of 0.5 μM, KN-93 prevents the increase in left ventricular (LV) developed pressure observed during action potential prolongation and early afterdepolarizations, a process linked to the prevention of the rise in Ca2+-independent CaM kinase activity that occurs during early afterdepolarizations.

Molecular Weight	537.5
Formula	C26H30Cl2N2O4S
CAS No.	1956426-56-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KN-93 hydrochloride 1956426-56-4 KN-93 Hydrochloride KN 93 hydrochloride KN93 Hydrochloride KN 93 Hydrochloride KN93 hydrochloride inhibitor inhibit

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