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Peramivir
🥰Excellent
Catalog No. T21339Cas No. 330600-85-6
Alias RWJ270201, RWJ 270201, BCX1812, BCX 1812
Peramivir (BCX1812) is a highly selective influenza A and B neuraminidase inhibitor with antiviral activity and anti-cytokine effects, which can be used in the study of novel coronavirus and influenza virus infections.
Peramivir
🥰Excellent
Purity: 99.82%
Catalog No. T21339Alias RWJ270201, RWJ 270201, BCX1812, BCX 1812Cas No. 330600-85-6
Peramivir (BCX1812) is a highly selective influenza A and B neuraminidase inhibitor with antiviral activity and anti-cytokine effects, which can be used in the study of novel coronavirus and influenza virus infections.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $64 | In Stock | |
| 10 mg | $106 | In Stock | |
| 25 mg | $198 | In Stock | |
| 50 mg | $292 | In Stock | |
| 100 mg | $433 | In Stock | |
| 500 mg | $987 | In Stock |
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Purity:99.82%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Peramivir (BCX1812) is a highly selective influenza A and B neuraminidase inhibitor with antiviral activity and anti-cytokine effects, which can be used in the study of novel coronavirus and influenza virus infections. |
| Targets&IC50 | NA:IC50: 0.9-4.3 nM |
| In vitro | Peramivir (2-10 μM, 6-12 h) inhibits LPS-induced cytokine release from hPBMCs[4]. Peramivir (0.3125-40 μM, 4 h) is non-toxic to macrophages[4]. |
| In vivo | Peramivir (20-60 mg/kg, intraperitoneal injection, single dose) inhibits LPS-induced cytokine storm, attenuates acute lung injury, and prolongs survival in a mouse model of cytokine storm syndrome [4]. Peramivir (75 mg/kg, intramuscular injection once daily for 7 days) rescued BR/08 lethally attacked BALB scid mice in an immunosuppressed mouse model of influenza B virus infection [5]. |
| Synonyms | RWJ270201, RWJ 270201, BCX1812, BCX 1812 |
| Molecular Weight | 328.41 |
| Formula | C15H28N4O4 |
| Cas No. | 330600-85-6 |
| Smiles | [C@@H](C(CC)CC)(NC(C)=O)[C@]1([C@H](NC(=N)N)C[C@H](C(O)=O)[C@H]1O)[H] |
| Relative Density. | 1.39 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: < 1 mg/mL (insoluble or slightly soluble.) |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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