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Pimurutamab
Catalog No. T80612 Copy Product Info
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Pimurutamab is a humanized monoclonal antibody modified by glycosylation engineering, which specifically targets epidermal growth factor receptor (EGFR/HER1). By binding to the extracellular domain of EGFR, Pimurutamab blocks its binding to ligands such as EGF and TGF-α, and inhibits receptor dimerization and downstream signal transduction. In addition, the optimized glycosylation modification significantly enhanced its antibody-dependent cell-mediated cytotoxicity (ADCC), making it show good potential in the treatment of solid tumors with high EGFR expression.
Pimurutamab
Copy Product Info🥰Excellent
Catalog No. T80612
Pimurutamab is a humanized monoclonal antibody modified by glycosylation engineering, which specifically targets epidermal growth factor receptor (EGFR/HER1). By binding to the extracellular domain of EGFR, Pimurutamab blocks its binding to ligands such as EGF and TGF-α, and inhibits receptor dimerization and downstream signal transduction. In addition, the optimized glycosylation modification significantly enhanced its antibody-dependent cell-mediated cytotoxicity (ADCC), making it show good potential in the treatment of solid tumors with high EGFR expression.
Cas No. 2251771-76-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Pimurutamab is a humanized monoclonal antibody modified by glycosylation engineering, which specifically targets epidermal growth factor receptor (EGFR/HER1). By binding to the extracellular domain of EGFR, Pimurutamab blocks its binding to ligands such as EGF and TGF-α, and inhibits receptor dimerization and downstream signal transduction. In addition, the optimized glycosylation modification significantly enhanced its antibody-dependent cell-mediated cytotoxicity (ADCC), making it show good potential in the treatment of solid tumors with high EGFR expression. |
| In vitro | In macrophage-mediated phagocytosis assays using human cancer cell lines, Pimurutamab (ATG-031) (nanomolar concentrations) blocked the CD24-Siglec-10 interaction and significantly enhanced the engulfment of tumor cells [1]. |
| In vivo | In human tumor xenograft models, systemic administration of Pimurutamab (ATG-031) significantly suppressed tumor growth and demonstrated synergistic effects when combined with PD-L1 inhibitors [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | EGFR |
| Cas No. | 2251771-76-1 |
| Isotype | IgG1 |
| Storage | Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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