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3,5-Dinitrocatechol

🥰Excellent
Catalog No. T23109Cas No. 7659-29-2

OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex.

3,5-Dinitrocatechol

3,5-Dinitrocatechol

🥰Excellent
Purity: 99.8%
Catalog No. T23109Cas No. 7659-29-2
OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex.
Pack SizePriceAvailabilityQuantity
5 mg$32In Stock
10 mg$46In Stock
50 mgPreferentialIn Stock
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Purity:99.8%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex.
Targets&IC50
COMT:12 nM
In vitro
OR-486 is highly effective (IC50 = 12 nM) and selective in inhibiting COMT activity in vitro[3].
In vivo
In mouse trachea (β1-AR dominant), significant suppression of ISO-induced relaxation was observed with the addition of OR-486. In GP trachea, in the presence of clorgiline plus OR-486, both normetadrenaline (NMA) and metadrenaline (MA) (10-4 M) significantly suppressed ISO-induced relaxation[1].
Chemical Properties
Molecular Weight200.11
FormulaC6H4N2O6
Cas No.7659-29-2
SmilesOC1=CC(=CC(=C1O)[N+]([O-])=O)[N+]([O-])=O
Relative Density.1.819 g/cm3 (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: < 20.01 mg/mL, Sonication is recommended.
DMSO: 50 mg/mL (249.86 mM), Sonication is recommended.
H2O: 0.17 mg/mL (0.85 mM), Sonication is recommended.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

OR-486OR486OR 486molybdenumInhibitorinhibitCOMT3,5-Dinitropyrocatechol3,5-Dinitrocatechol3,5Dinitrocatechol3,5 Dinitrocatechol
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