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Substance P acetate

Name: Substance P acetate
Brand: TargetMol
SKU: TP1087L
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1087L

Alias Substance P acetate (33507-63-0 Free base), Neurokinin P acetate

Substance P acetate is a peptide mainly secreted by neurons and is involved in many biological processes including nociception and inflammation. Substance P acetate is a neuroinflammatory factor that can act as a neurotransmitter and neuromodulator in the central nervous system and can be used to study cardiovascular and neurological diseases.

Substance P acetate

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Purity: 98.81%

Catalog No. TP1087LAlias Substance P acetate (33507-63-0 Free base), Neurokinin P acetate

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	-	In Stock
5 mg	$108	-	In Stock
10 mg	$197	-	In Stock
25 mg	$372	-	In Stock
50 mg	$548	-	In Stock
100 mg	$779	-	In Stock
500 mg	$1,570	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.81%

Appearance:Solid

Color:White

Resource Download

COA HPLC MS

Product Introduction

Bioactivity

Description	Substance P acetate is a peptide mainly secreted by neurons and is involved in many biological processes including nociception and inflammation. Substance P acetate is a neuroinflammatory factor that can act as a neurotransmitter and neuromodulator in the central nervous system and can be used to study cardiovascular and neurological diseases.
In vitro	Desensitization and resensitization of Substance P (SP) mediated by the neurokinin 1 receptor (NK1-R) may be related to endocytosis and recycling of NK1-R. SP is intact at the cell surface and in early nuclear endosomes but is slowly degraded in perinuclear vesicles. substance P acetate induces lattice protein-dependent internalization of the NK1-R. SP/ NK1-R complex dissociates in acidified nuclear endosomes, SP is degraded, and NK1-R is recycled to the cell surface.Substance P acetate induces internalization of NK1-R in transfected epithelial cells. [1]
Synonyms	Substance P acetate (33507-63-0 Free base), Neurokinin P acetate

Chemical Properties

Molecular Weight	1407.68
Formula	C₆₅H₁₀₂N₁₈O₁₅S
Smiles	O=C([C@H]1N(CCC1)C([C@@H](N)CCCNC(N)=N)=O)N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4)=O)=O)=O)=O.CC(O)=O
Sequence	H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Sequence Short	RPKPQQFFGLM

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (35.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7104 mL	3.5519 mL	7.1039 mL	35.5194 mL
5 mM	0.1421 mL	0.7104 mL	1.4208 mL	7.1039 mL
10 mM	0.0710 mL	0.3552 mL	0.7104 mL	3.5519 mL
20 mM	0.0355 mL	0.1776 mL	0.3552 mL	1.7760 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc