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BN201
😃Good
Catalog No. T14693Cas No. 1361200-34-1
Alias OCS05, OCS 05, G-79, BN 201, ACT-01, ACT01
BN201 (OCS-05) is a drug with neuroprotective and myelin repair effects, which acts mainly by activating serum glucocorticoid kinase-2 (SGK2), which in turn activates the FOXO3 pathway to promote neuronal survival and myelin repair. It is mainly used for the treatment of inflammatory neurological diseases such as multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).BN201 is able to regulate multiple kinases in the insulin growth factor 1 (IGF1) pathway and cross the blood-brain barrier.
BN201
😃Good
Purity: 99.42%
Catalog No. T14693Alias OCS05, OCS 05, G-79, BN 201, ACT-01, ACT01Cas No. 1361200-34-1
BN201 (OCS-05) is a drug with neuroprotective and myelin repair effects, which acts mainly by activating serum glucocorticoid kinase-2 (SGK2), which in turn activates the FOXO3 pathway to promote neuronal survival and myelin repair. It is mainly used for the treatment of inflammatory neurological diseases such as multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).BN201 is able to regulate multiple kinases in the insulin growth factor 1 (IGF1) pathway and cross the blood-brain barrier.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $239 | 6-8 weeks | 6-8 weeks | |
| 5 mg | $596 | 6-8 weeks | 6-8 weeks | |
| 10 mg | $893 | 6-8 weeks | 6-8 weeks | |
| 25 mg | $1,330 | 1-2 weeks | 1-2 weeks | |
| 50 mg | $1,860 | - | In Stock | |
| 100 mg | $2,480 | 1-2 weeks | 1-2 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.42%
Appearance:Viscous
Color:Transparent
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BN201 (OCS-05) is a drug with neuroprotective and myelin repair effects, which acts mainly by activating serum glucocorticoid kinase-2 (SGK2), which in turn activates the FOXO3 pathway to promote neuronal survival and myelin repair. It is mainly used for the treatment of inflammatory neurological diseases such as multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).BN201 is able to regulate multiple kinases in the insulin growth factor 1 (IGF1) pathway and cross the blood-brain barrier. |
| In vitro | Methods: RN22 cells were treated with BN201 (1-10-50 ng/ml or 1-10 μg/ml, 24 hours). Human SH-SY5Y neuroblastoma cells treated with BN201 (0.03, 0.1, 0.5, 1, 3, 5, 10, 20 and 100 μM) were treated with retinoic acid (10 μM, 6 days) and MPP+ (100 μM) or H2O2 (100 μM) were added 30 minutes later. Cell viability was measured by MTT assay. Results: BN201 had the strongest activity in protecting SH-SY5Y and RN22 cells from oxidative stress. [1] |
| In vivo | Methods: Female C57BL/6 mice immunized with MOG35-55 were treated with BN201 (12.5, 25, 50, 100 mg/kg, intraperitoneally, for 30 days) to evaluate its effect in protecting neurons and myelin-producing cells in vivo. Results: BN201-treated mice had less axonal and neuronal loss in the spinal cord and optic nerves. [1] |
| Synonyms | OCS05, OCS 05, G-79, BN 201, ACT-01, ACT01 |
| Molecular Weight | 491.6 |
| Formula | C25H38FN5O4 |
| Cas No. | 1361200-34-1 |
| Smiles | O=C(N)CN(C(=O)CN(C(=O)CNCCC=1C=CC=CC1F)CC(C)C)CCCN2C(=O)CCC2 |
| Relative Density. | 1.192 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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