DKK1 Protein, Human, Recombinant (His) V2

Name: DKK1 Protein, Human, Recombinant (His) V2
Brand: TargetMol
SKU: TMPY-00775U
Rating: 4.5 (1 reviews)

(Synonyms: SK, DKK-1, dickkopf WNT signaling pathway inhibitor 1) Copy Product Info

Synonyms: SK, DKK-1, dickkopf WNT signaling pathway inhibitor 1

Catalog No. TMPY-00775U Copy Product Info

DKK1 Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is O94907.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$90	7-10 days	7-10 days
10 µg	$145	7-10 days	7-10 days
20 µg	$240	7-10 days	7-10 days
50 µg	$438	7-10 days	7-10 days
100 µg	$700	7-10 days	7-10 days
200 µg	$1,200	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized Human DKK1, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Human LRP-5, mFc Tag with the EC50 of 1.7 μg/ml determined by ELISA.
Description	DKK1 Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is O94907.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	O94907
Construction	Thr32-His266
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in 20 mM PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	SK, DKK-1, dickkopf WNT signaling pathway inhibitor 1
Research Background	Dickkopf related protein 1 (Dkk-1) is the founding member of the Dickkopf family of proteins that includes Dkk-1, -2, -3, -4, and a related protein, Soggy. Dkk proteins are secreted proteins that contain two conserved cysteine-rich domains separated by a linker region. Dkk antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation.

Chemical Properties

Molecular Weight

26.87 kDa (Predicted); 42-52 kDa (Due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.