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Anti-NTH1 Antibody (7B232)

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Catalog No. TMAB-09659

Anti-NTH1 Antibody (7B232) is a Rabbit antibody targeting NTH1. Anti-NTH1 Antibody (7B232) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.

Anti-NTH1 Antibody (7B232)

Anti-NTH1 Antibody (7B232)

😃Good
Catalog No. TMAB-09659
Anti-NTH1 Antibody (7B232) is a Rabbit antibody targeting NTH1. Anti-NTH1 Antibody (7B232) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1497-10 days7-10 days
50 μL$2627-10 days7-10 days
100 μL$4727-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-NTH1 Antibody (7B232) is a Rabbit antibody targeting NTH1. Anti-NTH1 Antibody (7B232) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
Clone
7B232
Reactivity
Human
Application
WB
IHC-P
IHC-Fr
ICC/IF
IF
Recommended Dose
WB: 1:500-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; ICC/IF: 1:50-200; IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus.
Tissue SpecificityWidely expressed with highest levels in heart and lowest levels in lung and liver.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundHas both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions.
Antigen Details
Immunogen
A synthesized peptide: human NTH1
Antigen Species
Human
Gene Name
NTHL1
Gene ID
4913
Protein Name
Endonuclease III-like protein 1
Uniprot ID
P78549
Function
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
Chemical Properties
Molecular WeightTheoretical: 34 kDa. Actual: 34 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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