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Abietic Acid

Name: Abietic Acid
Brand: TargetMol
SKU: T3090
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3090Cas No. 514-10-3

Alias Sylvic acid, Rosin Acid, L-Abietic acid

Abietic Acid (Sylvic acid) is a diterpene extracted from Pimenta racemosavar. grissea with antimicrobial, antiproliferative and anti-obesity activities. It inhibits lipoxygenase activity and may be studied in allergic diseases.

Abietic Acid

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Catalog No. T3090Alias Sylvic acid, Rosin Acid, L-Abietic acidCas No. 514-10-3

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$45	-	In Stock
25 mg	$68	-	In Stock
50 mg	$98	-	In Stock
100 mg	$146	-	In Stock
500 mg	$358	-	In Stock
1 mL x 10 mM (in DMSO)	$44	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Abietic Acid AI Summary

Abietic Acid displays a wide range of bioactivities. It inhibits pyruvate dehydrogenase kinase with an IC50 value of 20,000 nM and demonstrates in vivo efficacy in diabetic mice with a dose of 200 umol/kg/day, showing efficacy levels between 22.0% to 45.0%. It inhibits COX2 activity by less than 30.0% at a concentration of 100 uM and shows antimicrobial activity against Propionibacterium acnes with an MIC of 25.0 ug/mL. Additionally, it exhibits cytotoxicity towards human HeLa and Vero cells with CC50 values of 14.9 ug/mL and 52.5 ug/mL, respectively, and is more toxic to Vero cells with a selectivity index of 3.5. Abietic Acid shows antifungal activity against Trametes versicolor and Gloeophyllum trabeum, and antibacterial activity with various MIC values against pathogens such as Staphylococcus aureus, Escherichia coli, and methicillin-resistant Staphylococcus aureus among others. It inhibits SARS coronavirus 3C-like protease activity with significant inhibition percentages and IC50 values. The compound also modulates Lamin A splicing, inhibits Histone Lysine Methyltransferase G9a and the vitamin D receptor, affects malarial parasite plastid, and inhibits Glutaminase. Furthermore, it impairs sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells, with notable inhibitory percentages and Ki values. Abietic Acid does not show significant cytotoxic activity against human PC3 and A549 cells but does exhibit weak cytotoxic activity against human SKOV3 cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Abietic Acid (Sylvic acid) is a diterpene extracted from Pimenta racemosavar. grissea with antimicrobial, antiproliferative and anti-obesity activities. It inhibits lipoxygenase activity and may be studied in allergic diseases.
Targets&IC50	5-LOX:29.5 μM
In vitro	METHODS: Different concentrations of Abietic Acid (Sylvic acid) (20, 40, 80, 160 and 320 µmol/l) were added to the cell culture medium of RAW264.7 cells and then incubation was continued for 26 hours. In order for Abietic Acid (Sylvic acid) treatment to have an effect on inflammatory mediator secretion, different concentrations of Abietic Acid (Sylvic acid) (20, 40 and 80 µmol/l) were added to the cell culture medium of RAW264.7 cells and incubated for 2 h. Then 1 µg/ml LPS was added to the cell culture medium of RAW264.7 cells and incubation was continued for 24 h. The cell culture medium of RAW264.7 cells was then incubated for 2 h. The cell culture medium of RAW264.7 cells was then incubated for 24 h. RESULTS Low concentrations (20, 40 and 80 µmol/l) of Abietic Acid (Sylvic acid) did not affect the viability of RAW264.7 cells, while high concentrations (160 and 320 µmol/l) of Abietic Acid (Sylvic acid) decreased the viability of RAW264.7 cells. Low concentrations of Abietic Acid (Sylvic acid) significantly reduced the concentrations of IL-1β, TNF-α, IL-6 and MIP-2 induced by LPS in the cell culture medium of RAW264.7 cells. [2]
In vivo	METHODS: Swiss mice (Mus musculus) were treated orally in 50, 100, and 200 mg/kg of Abietic Acid (Sylvic acid) central nervous system (CNS) effects were assessed using open-field and rotational assays, and anti-oedema activity was investigated by measuring carrageenan, dextran, histamine, arachidonic acid, and prostaglandin-induced paw edema. RESULTS Oral administration of Abietic Acid (Sylvic acid) (200 mg/kg) showed no evidence of CNS effects, and the compound also exhibited significant anti-edema and anti-inflammatory activity in carrageenan and dextrose models. [1]
Synonyms	Sylvic acid, Rosin Acid, L-Abietic acid

Chemical Properties

Molecular Weight	302.45
Formula	C₂₀H₃₀O₂
Cas No.	514-10-3
Smiles	[H][C@]12CCC(=CC1=CCC1[C@@](C)(CCC[C@]21C)C(O)=O)C(C)C
Relative Density.	1.06g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (198.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3063 mL	16.5317 mL	33.0633 mL	165.3166 mL
5 mM	0.6613 mL	3.3063 mL	6.6127 mL	33.0633 mL
10 mM	0.3306 mL	1.6532 mL	3.3063 mL	16.5317 mL
20 mM	0.1653 mL	0.8266 mL	1.6532 mL	8.2658 mL
50 mM	0.0661 mL	0.3306 mL	0.6613 mL	3.3063 mL
100 mM	0.0331 mL	0.1653 mL	0.3306 mL	1.6532 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc