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Anti-DNAH1 Polyclonal Antibody
😃Good
Catalog No. TMAB-05223
Anti-DNAH1 Polyclonal Antibody is a Rabbit antibody targeting DNAH1. Anti-DNAH1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-DNAH1 Polyclonal Antibody
Anti-DNAH1 Polyclonal Antibody
😃Good
Catalog No. TMAB-05223
Anti-DNAH1 Polyclonal Antibody is a Rabbit antibody targeting DNAH1. Anti-DNAH1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-DNAH1 Polyclonal Antibody is a Rabbit antibody targeting DNAH1. Anti-DNAH1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Pig,Cow,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm > cytoskeleton > cilium axoneme. |
| Tissue Specificity | Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Axonemal Dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. DNAH1 (dynein heavy chain 1, axonemal), also known as heat shock regulated protein 1 or ciliary dynein heavy chain 1, is a 4,330 amino acid protein consisting of at least two heavy chains and several intermediate and light chains. Mutations in the gene encoding DNAH1 may be a cause of primary ciliary dyskinesia, also known as Kartagener Syndrome, which is characterized by chronic recurrent respiratory infections due to defective cilia action in the respiratory tract. There are three isoforms of DNAH1 that exist as a result of alternative splicing events. |
| Immunogen | KLH conjugated synthetic peptide: human DNAH1 |
| Antigen Species | Human |
| Gene Name | DNAH1 |
| Gene ID | |
| Protein Name | Dynein heavy chain 1, axonemal |
| Uniprot ID | |
| Function | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. |
| Molecular Weight | Theoretical: 494 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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