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Tryptamine

Name: Tryptamine
Brand: TargetMol
SKU: T0647
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0647Cas No. 61-54-1

Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It is found in trace amounts in the brains of mammals and is recognized to play a role as a neurotransmitter or neuromodulator.

Tryptamine

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Purity: 98.59%

Catalog No. T0647Cas No. 61-54-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$30	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.59%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Tryptamine AI Summary

Tryptamine exhibits a broad spectrum of bioactivities and binding affinities, indicating potential pharmacological applications. It shows significant interaction with various serotonin receptors, particularly with high affinity for 5-HT1D (Ki values of 23.0 nM, 36.0 nM, and 61.0 nM in different assays) and moderate affinity for 5-HT6 (Ki = 70.0 nM). Additionally, it binds to 5-HT1A, 1B, 2C, and 2 receptors (Ki values ranging from 50.0 nM to 10200.0 nM), and exhibits bioactivity at 5-HT7 (Ki = 158.49 nM). Tryptamine shows binding affinity and functional activity towards imidazoline receptor I-2 (Ki = 5400.0 nM), alpha-2 adrenergic receptors (Ki = 19000.0 nM), and presents notable agonistic activity at the TAAR1 receptor (EC50 = 2210.0 nM). In enzymatic assays, Tryptamine demonstrates inhibitory properties against various enzymes including the SARS-CoV-2 3CL-Pro protease (17.65% inhibition at 20 µM), CYP2A family (competitive inhibition with Ki values of 1700.0 nM and 16000.0 nM for CYP2A6 and CYP2A13, respectively), and IDO1 (noncompetitive inhibitor, Ki = 160,000.0 nM). It also shows activity against the human MPO enzyme (IC50 = 770.0 nM) and cathepsin K (IC50 = 15000.0 nM). Furthermore, Tryptamine displays antifungal activity against Candida albicans biofilm formation (MBIC50 = 128.0 µg/mL) and demonstrates antibacterial activities against multiple bacterial strains, although with relatively high MIC values (>51.0 µg/mL). Its potential CNS activity is indicated by its effect on neurotransmitter release (EC50 values of 32.6 nM for serotonin, 164.0 nM for dopamine, and 716.0 nM for norepinephrine). Tryptamine also exhibits modest antiviral activities against SARS-CoV-2 and various virus-induced cytotoxicities at micromolar concentrations. The compound has additional pharmacological effects, including NFkB signaling pathway modulation, cytochrome activity modulation, Nrf2 inhibition, JMJD2A-Tudor domain inhibition, D1 dopamine receptor potentiation, and inhibition of HIV-1 Vif-dependent degradation of human APOBEC3G. It also inhibits mycelial growth of Leptosphaeria maculans and displays varying levels of oxidative stress mitigation (IC50 values from 6000.0 nM to 682000.0 nM). Notable properties of Tryptamine include a binding energy of 7.9 kCal/mol, log P of 1.35, intrinsic water solubility of 80.0 µg/mL, and permeability coefficient logP app = -5.27. Overall, these diverse bioactivities suggest that Tryptamine is a multi-target agent with potential applications across a range of therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It is found in trace amounts in the brains of mammals and is recognized to play a role as a neurotransmitter or neuromodulator.
Targets&IC50	TAAR1 (human):1.08 μM(Ki)

Chemical Properties

Molecular Weight	160.22
Formula	C₁₀H₁₂N₂
Cas No.	61-54-1
Smiles	NCCC1=CNC2=CC=CC=C12
Relative Density.	1.16 g/cm3. Temperature:25 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (1529.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.2414 mL	31.2071 mL	62.4142 mL	312.0709 mL
5 mM	1.2483 mL	6.2414 mL	12.4828 mL	62.4142 mL
10 mM	0.6241 mL	3.1207 mL	6.2414 mL	31.2071 mL
20 mM	0.3121 mL	1.5604 mL	3.1207 mL	15.6035 mL
50 mM	0.1248 mL	0.6241 mL	1.2483 mL	6.2414 mL
100 mM	0.0624 mL	0.3121 mL	0.6241 mL	3.1207 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc